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CHEBI:60773 - porfimer sodium

ChEBI IDCHEBI:60773
ChEBI Nameporfimer sodium
Stars
DefinitionThe sodium salt of porfimer. The purified component of haematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins formed by ether and ester linkages of up to eight porphyrin units (n = 0-6), where R = CH(OH)Me and/or CH=CH2. After addition of hydrochloric acid and/or sodium hydroxide to pH 7.2 - 7.9, it is used as a photosensitiser in photodynamic therapy of non-small cell lung cancer, oesophageal cancer, and superficial bladder cancer. The drug is administered by slow intravenous injection and accumulates in malignant tissue. After 40-50 hours, it is activated by laser light at 630 nm, delivered to the tumour using a fibre optic guide. Subsequent spin transfer to oxygen molecules within the tissue, generates highly reactive singlet oxygen, and subsequent radical reactions generate superoxide and hydroxyl radicals. Propagation of radical reactions ultimately kills the tumour cells.
Last Modified21 March 2019
SubmitterGareth Owen
DownloadsMolfile
Formula(C32H32N4O4R)0-6.C64H64N8Na5O9R2
Net Charge0
Average Mass (excl. R groups)0.000
Monoisotopic Mass (excl. R groups)0.00000
SMILES*C1=C(C)C2Cc3nc(c(C)c3C(C)OC(=O)CCc3c(C)/c4n/c3=C\C3=N/C(=C\c5nc(c(C(C)OC(C)c6c7nc(c6C)/C=C6\N=C(/C=c8\n/c(c(C)c8CCC(=O)[O-])=C\C8=NC(C7)C(C)=C8*)C(CCC(=O)[O-])=C6C)c5C)CC5N=C(/C=4)C(*)=C5C)C(C)=C3CCC(=O)[O-])/C=C3\N=C(/C=c4\n/c(c(C)c4CCC(=O)[O-])=C\C1=N2)C(CCC(=O)[O-])=C3C.[Na+].[Na+].[Na+].[Na+].[Na+]
Roles Classification
Biological Role:
antiviral agent  A substance that destroys or inhibits replication of viruses.
Applications:
photosensitizing agent  A chemical compound that can be excited by light of a specific wavelength and subsequently transfer energy to a chosen reactant. This is commonly molecular oxygen within a cancer tissue, which is converted to (highly rective) singlet state oxygen. This rapidly reacts with any nearby biomolecules, ultimately killing the cancer cells.
dermatologic drug  A drug used to treat or prevent skin disorders or for the routine care of skin.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
porfimer sodium (CHEBI:60773) has part porfimer anion (CHEBI:60774)
porfimer sodium (CHEBI:60773) has role antineoplastic agent (CHEBI:35610)
porfimer sodium (CHEBI:60773) has role antiviral agent (CHEBI:22587)
porfimer sodium (CHEBI:60773) has role dermatologic drug (CHEBI:50177)
porfimer sodium (CHEBI:60773) has role photosensitizing agent (CHEBI:47868)
porfimer sodium (CHEBI:60773) is a organic sodium salt (CHEBI:38700)
INNs  Source
porfimer sodicoChemIDplus
porfimerum natricumChemIDplus
porfimer sodiumChemIDplus
porfimere sodiqueChemIDplus
Brand Name  Source
PhotofrinChemIDplus
Manual XrefsDatabases
DB00707DrugBank
Registry NumbersSources
Reaxys:8537222Reaxys
CAS:87806-31-3ChemIDplus