EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:60761 - floxuridine

ChEBI IDCHEBI:60761
ChEBI Namefloxuridine
Stars
DefinitionA pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
Last Modified25 May 2018
SubmitterSteve
DownloadsMolfile
FormulaC9H11FN2O5
Net Charge0
Average Mass246.194
Monoisotopic Mass246.06520
SMILESO=c1nc(=O)n([C@H]2C[C@H](O)[C@@H](CO)O2)cc1F
InChIInChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChIKeyODKNJVUHOIMIIZ-RRKCRQDMSA-N
Wikipedia
Roles Classification
Biological Roles:
antimetabolite  A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization.
antiviral drug  A substance used in the prophylaxis or therapy of virus diseases.
Applications:
radiosensitizing agent  A drug that makes increases the sensitivity of tumour cells to radiation therapy.
antiviral drug  A substance used in the prophylaxis or therapy of virus diseases.
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
floxuridine (CHEBI:60761) has role antimetabolite (CHEBI:35221)
floxuridine (CHEBI:60761) has role antineoplastic agent (CHEBI:35610)
floxuridine (CHEBI:60761) has role antiviral drug (CHEBI:36044)
floxuridine (CHEBI:60761) has role radiosensitizing agent (CHEBI:132992)
floxuridine (CHEBI:60761) is a nucleoside analogue (CHEBI:60783)
floxuridine (CHEBI:60761) is a organofluorine compound (CHEBI:37143)
floxuridine (CHEBI:60761) is a pyrimidine 2'-deoxyribonucleoside (CHEBI:19255)
IUPAC Name 
5-fluoro-2'-deoxyuridine
INNs  Source
floxiridinaDrugBank
floxuridineKEGG DRUG
floxuridinumDrugBank
Synonyms  Source
1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracilChemIDplus
1-beta-D-2'-Deoxyribofuranosyl-5-flurouracilChemIDplus
1beta-D-2'-Deoxyribofuranosyl-5-flurouracilChemIDplus
2'-Deoxy-5-fluorouridineChemIDplus
5FDUDrugBank
5-fluoro-2'-deoxyuridineChEBI
Manual XrefsDatabases
1184DrugCentral
C11736KEGG COMPOUND
D04197KEGG DRUG
DB00322DrugBank
FloxuridineWikipedia
HMDB0014467HMDB
LSM-5588LINCS
Registry NumbersSources
Reaxys:90221Reaxys
CAS:50-91-9KEGG DRUG
CAS:50-91-9KEGG COMPOUND
CAS:50-91-9ChemIDplus
CAS:50-91-9NIST Chemistry WebBook
Citations