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CHEBI:59586 - clodronic acid disodium salt

ChEBI IDCHEBI:59586
ChEBI Nameclodronic acid disodium salt
Stars
DefinitionThe disodium salt of clodronic acid. It inhibits bone resorption and soft tissue calcification, and is used (generally as the tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.
Last Modified12 June 2012
SubmitterGareth Owen
DownloadsMolfile
FormulaCH2Cl2O6P2.2Na
Net Charge0
Average Mass288.855
Monoisotopic Mass287.84990
SMILESO=P([O-])(O)C(Cl)(Cl)P(=O)([O-])O.[Na+].[Na+]
InChIInChI=1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
InChIKeyHJKBJIYDJLVSAO-UHFFFAOYSA-L
Roles Classification
Application:
bone density conservation agent  An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis.
ChEBI Ontology
Outgoing Relation(s)
clodronic acid disodium salt (CHEBI:59586) has part clondronate(2−) (CHEBI:59585)
clodronic acid disodium salt (CHEBI:59586) has role bone density conservation agent (CHEBI:50646)
clodronic acid disodium salt (CHEBI:59586) is a one-carbon compound (CHEBI:64708)
clodronic acid disodium salt (CHEBI:59586) is a organic sodium salt (CHEBI:38700)
Incoming Relation(s)
disodium clodronate tetrahydrate (CHEBI:59587) has part clodronic acid disodium salt (CHEBI:59586)
IUPAC Name 
disodium (dichloromethanediyl)bis[hydrogen (phosphonate)]
Synonyms  Source
clodronate disodiumKEGG DRUG
clodronic acid disodium saltKEGG DRUG
clodronate sodiumChemIDplus
disodium (dichloromethylene)bisphosphonateChemIDplus
disodium dichloromethylene diphosphonateChemIDplus
disodium dihydrogen (dichloromethylene)diphosphonateChemIDplus
Manual XrefsDatabases
D07720KEGG DRUG
Registry NumbersSources
Beilstein:5841154Beilstein
CAS:22560-50-5KEGG DRUG
CAS:22560-50-5ChemIDplus