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CHEBI:585948 - felodipine

ChEBI IDCHEBI:585948
ChEBI Namefelodipine
Stars
DefinitionThe mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.
Secondary ChEBI IDsCHEBI:4996, CHEBI:49383
Last Modified22 February 2017
DownloadsMolfile
FormulaC18H19Cl2NO4
Net Charge0
Average Mass384.259
Monoisotopic Mass383.06911
SMILESCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC)C1c1cccc(Cl)c1Cl
InChIInChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
InChIKeyRZTAMFZIAATZDJ-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
calcium channel blocker  One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools.
Applications:
anti-arrhythmia drug  A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
vasodilator agent  A drug used to cause dilation of the blood vessels.
ChEBI Ontology
Outgoing Relation(s)
felodipine (CHEBI:585948) has role anti-arrhythmia drug (CHEBI:38070)
felodipine (CHEBI:585948) has role antihypertensive agent (CHEBI:35674)
felodipine (CHEBI:585948) has role calcium channel blocker (CHEBI:38215)
felodipine (CHEBI:585948) has role vasodilator agent (CHEBI:35620)
felodipine (CHEBI:585948) is a dichlorobenzene (CHEBI:23697)
felodipine (CHEBI:585948) is a dihydropyridine (CHEBI:50075)
felodipine (CHEBI:585948) is a ethyl ester (CHEBI:23990)
felodipine (CHEBI:585948) is a methyl ester (CHEBI:25248)
IUPAC Name 
ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
INNs  Source
felodipinaChemIDplus
felodipineChemIDplus
felodipinumChemIDplus
Synonyms  Source
FELODIPINEPDBeChem
(±)-ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylateChemIDplus
3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylateNIST Chemistry WebBook
4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl esterChEBI
Manual XrefsDatabases
225PDBeChem
D00319KEGG DRUG
EP7293Patent
US4264611Patent
DB01023DrugBank
FelodipineWikipedia
LSM-1447LINCS
1142DrugCentral
Registry NumbersSources
Reaxys:4331472Reaxys
CAS:72509-76-3NIST Chemistry WebBook
CAS:72509-76-3ChemIDplus
CAS:72509-76-3KEGG DRUG
Citations