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CHEBI:5784 - hydroflumethiazide

Default Structure
ChEBI IDCHEBI:5784
ChEBI Namehydroflumethiazide
Stars
DefinitionA benzothiadiazine consisting of a 3,4-dihydro-HH-1,2,4-benzothiadiazine bicyclic system dioxygenated on sulfur and carrying trifluoromethyl and aminosulfonyl groups at positions 6 and 7 respectively. A diuretic with actions and uses similar to those of hydrochlorothiazide.
Last Modified12 June 2018
DownloadsMolfile
FormulaC8H8F3N3O4S2
Net Charge0
Average Mass331.297
Monoisotopic Mass330.99083
SMILESNS(=O)(=O)c1cc2c(cc1C(F)(F)F)NCNS2(=O)=O
InChIInChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16)
InChIKeyDMDGGSIALPNSEE-UHFFFAOYSA-N
Wikipedia
Roles Classification
Applications:
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
diuretic  An agent that promotes the excretion of urine through its effects on kidney function.
ChEBI Ontology
Outgoing Relation(s)
hydroflumethiazide (CHEBI:5784) has role antihypertensive agent (CHEBI:35674)
hydroflumethiazide (CHEBI:5784) has role diuretic (CHEBI:35498)
hydroflumethiazide (CHEBI:5784) is a benzothiadiazine (CHEBI:50265)
hydroflumethiazide (CHEBI:5784) is a thiazide (CHEBI:50264)
IUPAC Name 
6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
INNs  Source
hidroflumetiazidaWHO MedNet
hydroflumethiazideChemIDplus
hydrofluméthiazideWHO MedNet
hydroflumethiazidumWHO MedNet
Synonyms  Source
HydroflumethiazideKEGG COMPOUND
trifluoromethylhydrothiazideDrugCentral
Manual XrefsDatabases
1392DrugCentral
C07763KEGG COMPOUND
D00654KEGG DRUG
HydroflumethiazideWikipedia
LSM-5497LINCS
Registry NumbersSources
Reaxys:342692Reaxys
CAS:135-09-1ChemIDplus
CAS:135-09-1KEGG COMPOUND
Citations