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CHEBI:57451 - dihydrofolate(2−)

ChEBI IDCHEBI:57451
ChEBI Namedihydrofolate(2−)
Stars
ASCII Namedihydrofolate(2-)
DefinitionDianion of dihydrofolic acid arising from deprotonation of both carboxylic acid functions.
Last Modified21 January 2016
DownloadsMolfile
FormulaC19H19N7O6
Net Charge-2
Average Mass441.404
Monoisotopic Mass441.14078
SMILESNc1nc2c(c(=O)n1)N=C(CNc1ccc(C(=O)N[C@@H](CCC(=O)[O-])C(=O)[O-])cc1)CN2
InChIInChI=1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/p-2/t12-/m0/s1
InChIKeyOZRNSSUDZOLUSN-LBPRGKRZSA-L
Species of MetaboliteComponentSourceComments
Homo sapiens (ncbitaxon:9606) - DOI (10.1038/nbt.2488)
Saccharomyces cerevisiae (ncbitaxon:4932) - PubMed (24678285) Source: yeast.sf.net
Roles Classification
Biological Roles:
human metabolite  Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
Saccharomyces cerevisiae metabolite  Any fungal metabolite produced during a metabolic reaction in Baker's yeast (Saccharomyces cerevisiae ).
water-soluble vitamin (role)  Any vitamin that dissolves in water and readily absorbed into tissues for immediate use. Unlike the fat-soluble vitamins, they are not stored in the body and need to be replenished regularly in the diet and will rarely accumulate to toxic levels since they are quickly excreted from the body via urine.
Application:
nutraceutical  A product in capsule, tablet or liquid form that provide essential nutrients, such as a vitamin, an essential mineral, a protein, an herb, or similar nutritional substance.
ChEBI Ontology
Outgoing Relation(s)
dihydrofolate(2−) (CHEBI:57451) has role Saccharomyces cerevisiae metabolite (CHEBI:75772)
dihydrofolate(2−) (CHEBI:57451) has role human metabolite (CHEBI:77746)
dihydrofolate(2−) (CHEBI:57451) is a dicarboxylic acid dianion (CHEBI:28965)
dihydrofolate(2−) (CHEBI:57451) is a dihydrofolates (CHEBI:67014)
dihydrofolate(2−) (CHEBI:57451) is conjugate base of dihydrofolic acid (CHEBI:15633)
Incoming Relation(s)
dihydrofolic acid (CHEBI:15633) is conjugate acid of dihydrofolate(2−) (CHEBI:57451)
IUPAC Name 
N-(4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamate
Synonym  Source
dihydrofolate dianionChEBI
UniProt Name  Source
7,8-dihydrofolateUniProt