guanadrel sulfate (CHEBI:5556)

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CHEBI:5556 - guanadrel sulfate

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ChEBI ID	CHEBI:5556
ChEBI Name	guanadrel sulfate
Stars
Definition	An organic sulfate salt resulting from the reaction of 2 eq. guanadrel with 1 eq. sulfuric acid. A postganglionic adrenergic blocking agent formerly used for the management of hypertension, it has been largely superseded by other drugs less likely to cause orthostatic hypotension (dizzy spells on standing up or stretching).
Last Modified	25 May 2022
Downloads	Molfile

Formula	2C10H19N3O2.H2O4S
Net Charge	0
Average Mass	524.641
Monoisotopic Mass	524.26283
SMILES	N=C(N)NCC1COC2(CCCCC2)O1.N=C(N)NCC1COC2(CCCCC2)O1.O=S(=O)(O)O
InChI	InChI=1S/2C10H19N3O2.H2O4S/c211-9(12)13-6-8-7-14-10(15-8)4-2-1-3-5-10;1-5(2,3)4/h28H,1-7H2,(H4,11,12,13);(H2,1,2,3,4)
InChIKey	RTEVGQJRTFFMLL-UHFFFAOYSA-N

Roles Classification

Biological Role:	adrenergic antagonist An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists.
Applications:	adrenergic antagonist An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.

ChEBI Ontology

Outgoing Relation(s)
	guanadrel sulfate (CHEBI:5556) has part guanadrel(1+) (CHEBI:72602)
	guanadrel sulfate (CHEBI:5556) has role adrenergic antagonist (CHEBI:37887)
	guanadrel sulfate (CHEBI:5556) has role antihypertensive agent (CHEBI:35674)
	guanadrel sulfate (CHEBI:5556) is a organic sulfate salt (CHEBI:51337)

IUPAC Name
1-(1,4-dioxaspiro[4.5]dec-2-ylmethyl)guanidine sulfate

Synonyms	Source
bis{amino[(1,4-dioxaspiro[4.5]dec-2-ylmethyl)amino]methaniminium} sulfate	IUPAC
CL 1388R	ChemIDplus
CL-1388R	ChemIDplus
U 28288D	ChemIDplus
U-28,288D	ChemIDplus

Brand Names	Source
Anarel	ChEBI
Hylorel	KEGG DRUG

Manual Xrefs	Databases
D00607	KEGG DRUG
DBSALT000889	DrugBank

Registry Numbers	Sources
Reaxys:13410559	Reaxys
CAS:22195-34-2	ChemIDplus
CAS:22195-34-2	KEGG DRUG

Citations