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CHEBI:53289 - donepezil
| Formula | C24H29NO3 |
| Net Charge | 0 |
| Average Mass | 379.500 |
| Monoisotopic Mass | 379.21474 |
| SMILES | [H]C1(CC2CCN(Cc3ccccc3)CC2)Cc2cc(OC)c(OC)cc2C1=O |
| InChI | InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3 |
| InChIKey | ADEBPBSSDYVVLD-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | EC 3.1.1.7 (acetylcholinesterase) inhibitor An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of enzyme acetylcholinesterase (EC 3.1.1.7), which helps breaking down of acetylcholine into choline and acetic acid. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. EC 3.1.1.8 (cholinesterase) inhibitor An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of cholinesterase (EC 3.1.1.8). |
| Applications: | hypoglycemic agent A drug which lowers the blood glucose level. vulnerary A drug used in treating and healing of wounds. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. nootropic agent Any compound that improves mental functions such as cognition, memory, intelligence, motivation, attention, and concentration. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. antiparkinson drug A drug used in the treatment of Parkinson's disease. antipsychotic agent Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| donepezil (CHEBI:53289) has part (R)-donepezil (CHEBI:53292) |
| donepezil (CHEBI:53289) has part (S)-donepezil (CHEBI:53290) |
| donepezil (CHEBI:53289) has role antidepressant (CHEBI:35469) |
| donepezil (CHEBI:53289) has role antineoplastic agent (CHEBI:35610) |
| donepezil (CHEBI:53289) has role antiparkinson drug (CHEBI:48407) |
| donepezil (CHEBI:53289) has role antipsychotic agent (CHEBI:35476) |
| donepezil (CHEBI:53289) has role anxiolytic drug (CHEBI:35474) |
| donepezil (CHEBI:53289) has role EC 3.1.1.7 (acetylcholinesterase) inhibitor (CHEBI:38462) |
| donepezil (CHEBI:53289) has role EC 3.1.1.8 (cholinesterase) inhibitor (CHEBI:37733) |
| donepezil (CHEBI:53289) has role hypoglycemic agent (CHEBI:35526) |
| donepezil (CHEBI:53289) has role immunosuppressive agent (CHEBI:35705) |
| donepezil (CHEBI:53289) has role nootropic agent (CHEBI:66980) |
| donepezil (CHEBI:53289) has role vulnerary (CHEBI:73336) |
| donepezil (CHEBI:53289) is a racemate (CHEBI:60911) |
| donepezil (CHEBI:53289) is conjugate base of donepezil (1+) (CHEBI:145498) |
| Incoming Relation(s) |
| donepezil (1+) (CHEBI:145498) is conjugate acid of donepezil (CHEBI:53289) |
| INNs | Source |
|---|---|
| donepezil | ChemIDplus |
| donépézil | WHO MedNet |
| donepezilo | WHO MedNet |
| donepezilum | WHO MedNet |
| Synonyms | Source |
|---|---|
| D-797 | ChEMBL |
| Donaz | ChEMBL |
| Citations |
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