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CHEBI:53289 - donepezil
| Formula | C24H29NO3 |
| Net Charge | 0 |
| Average Mass | 379.500 |
| Monoisotopic Mass | 379.21474 |
| SMILES | [H]C1(CC2CCN(Cc3ccccc3)CC2)Cc2cc(OC)c(OC)cc2C1=O |
| InChI | InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3 |
| InChIKey | ADEBPBSSDYVVLD-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Roles Classification |
|---|
| Biological Roles: | EC 3.1.1.8 (cholinesterase) inhibitor An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of cholinesterase (EC 3.1.1.8). EC 3.1.1.7 (acetylcholinesterase) inhibitor An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of enzyme acetylcholinesterase (EC 3.1.1.7), which helps breaking down of acetylcholine into choline and acetic acid. |
| Application: | nootropic agent Any compound that improves mental functions such as cognition, memory, intelligence, motivation, attention, and concentration. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| donepezil (CHEBI:53289) has part (R)-donepezil (CHEBI:53292) |
| donepezil (CHEBI:53289) has part (S)-donepezil (CHEBI:53290) |
| donepezil (CHEBI:53289) has role EC 3.1.1.7 (acetylcholinesterase) inhibitor (CHEBI:38462) |
| donepezil (CHEBI:53289) has role EC 3.1.1.8 (cholinesterase) inhibitor (CHEBI:37733) |
| donepezil (CHEBI:53289) has role nootropic agent (CHEBI:66980) |
| donepezil (CHEBI:53289) is a racemate (CHEBI:60911) |
| donepezil (CHEBI:53289) is conjugate base of donepezil (1+) (CHEBI:145498) |
| Incoming Relation(s) |
| donepezil (1+) (CHEBI:145498) is conjugate acid of donepezil (CHEBI:53289) |
| INNs | Source |
|---|---|
| donepezil | ChemIDplus |
| donépézil | WHO MedNet |
| donepezilo | WHO MedNet |
| donepezilum | WHO MedNet |