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CHEBI:52998 - interleukins

ChEBI IDCHEBI:52998
ChEBI Nameinterleukins
Stars
DefinitionInterleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes), The term interleukine, (inter-) as a means of communication, (-leukin) deriving from the fact that many of these proteins are produced by leukocytes and act on leukocytes. The name is something of a relic though (the term was coined by Dr. Paetkau, University of Victoria); it has since been found that interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T, B, and hematopoietic cells.
Last Modified26 August 2009
Submittereleh
ChEBI Ontology
Outgoing Relation(s)
interleukins (CHEBI:52998) is a unclassifieds (CHEBI:27189)