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CHEBI:5118 - fluoxetine
| ChEBI ID | CHEBI:5118 |
| ChEBI Name | fluoxetine |
| Stars | |
| Definition | A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder. |
| Last Modified | 22 February 2017 |
| Formula | C17H18F3NO |
| Net Charge | 0 |
| Average Mass | 309.326 |
| Monoisotopic Mass | 309.13405 |
| Wikipedia |
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| Roles Classification |
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| Chemical Role: | environmental contaminant Any minor or unwanted substance introduced into the environment that can have undesired effects. |
| Biological Roles: | immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. antiviral agent A substance that destroys or inhibits replication of viruses. xenobiotic A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. anti-obesity agent Any substance which is used to reduce or control weight. drug allergen Any drug which causes the onset of an allergic reaction. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. |
| Applications: | antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. vulnerary A drug used in treating and healing of wounds. antipsychotic agent Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. anticonvulsant A drug used to prevent seizures or reduce their severity. serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. hypoglycemic agent A drug which lowers the blood glucose level. drug allergen Any drug which causes the onset of an allergic reaction. anxiolytic drug Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| fluoxetine (CHEBI:5118) has functional parent (trifluoromethyl)benzene (CHEBI:36810) |
| fluoxetine (CHEBI:5118) has part (R)-fluoxetine (CHEBI:86991) |
| fluoxetine (CHEBI:5118) has part (S)-fluoxetine (CHEBI:86992) |
| fluoxetine (CHEBI:5118) has role analgesic (CHEBI:35480) |
| fluoxetine (CHEBI:5118) has role anti-obesity agent (CHEBI:74518) |
| fluoxetine (CHEBI:5118) has role anticonvulsant (CHEBI:35623) |
| fluoxetine (CHEBI:5118) has role antidepressant (CHEBI:35469) |
| fluoxetine (CHEBI:5118) has role antihypertensive agent (CHEBI:35674) |
| fluoxetine (CHEBI:5118) has role antineoplastic agent (CHEBI:35610) |
| fluoxetine (CHEBI:5118) has role antipsychotic agent (CHEBI:35476) |
| fluoxetine (CHEBI:5118) has role antiviral agent (CHEBI:22587) |
| fluoxetine (CHEBI:5118) has role anxiolytic drug (CHEBI:35474) |
| fluoxetine (CHEBI:5118) has role drug allergen (CHEBI:88188) |
| fluoxetine (CHEBI:5118) has role environmental contaminant (CHEBI:78298) |
| fluoxetine (CHEBI:5118) has role hypoglycemic agent (CHEBI:35526) |
| fluoxetine (CHEBI:5118) has role immunosuppressive agent (CHEBI:35705) |
| fluoxetine (CHEBI:5118) has role serotonin uptake inhibitor (CHEBI:50949) |
| fluoxetine (CHEBI:5118) has role vulnerary (CHEBI:73336) |
| fluoxetine (CHEBI:5118) has role xenobiotic (CHEBI:35703) |
| fluoxetine (CHEBI:5118) is a racemate (CHEBI:60911) |
| IUPAC Name |
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| rac-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine |
| INNs | Source |
|---|---|
| fluoxetina | ChemIDplus |
| fluoxetine | KEGG DRUG |
| fluoxétine | WHO MedNet |
| fluoxetinum | ChemIDplus |
| Synonyms | Source |
|---|---|
| (±)-N-methyl-3-phenyl-3-((α,α,α-trifluoro-p-tolyl)oxy)propylamine | ChemIDplus |
| (±)-N-methyl-γ-(4-(trifluoromethyl)phenoxy)benzenepropanamine | ChemIDplus |
| Fluoxetin ratiopharm | ChEMBL |
| Fluval | ChEMBL |
| NSC-283480 | ChEMBL |
| NSC-758685 | ChEMBL |
| Brand Name | Source |
|---|---|
| Prozac | DrugBank |
| Manual Xrefs | Databases |
|---|---|
| D00326 | KEGG DRUG |
| DB00472 | DrugBank |
| DE2500110 | Patent |
| Fluoxetine | Wikipedia |
| HMDB0014615 | HMDB |
| US4314081 | Patent |
| Registry Numbers | Sources |
|---|---|
| Reaxys:3991406 | Reaxys |
| Beilstein:39914106 | Beilstein |
| CAS:54910-89-3 | ChemIDplus |
| CAS:54910-89-3 | KEGG DRUG |
| Citations |
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