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CHEBI:5118 - fluoxetine
| ChEBI ID | CHEBI:5118 |
| ChEBI Name | fluoxetine |
| Stars | |
| Definition | A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder. |
| Last Modified | 22 February 2017 |
| Formula | C17H18F3NO |
| Net Charge | 0 |
| Average Mass | 309.326 |
| Monoisotopic Mass | 309.13405 |
| Wikipedia |
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| Roles Classification |
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| Chemical Role: | environmental contaminant Any minor or unwanted substance introduced into the environment that can have undesired effects. |
| Biological Roles: | analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. xenobiotic A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. drug allergen Any drug which causes the onset of an allergic reaction. |
| Applications: | analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. drug allergen Any drug which causes the onset of an allergic reaction. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| fluoxetine (CHEBI:5118) has functional parent (trifluoromethyl)benzene (CHEBI:36810) |
| fluoxetine (CHEBI:5118) has part (R)-fluoxetine (CHEBI:86991) |
| fluoxetine (CHEBI:5118) has part (S)-fluoxetine (CHEBI:86992) |
| fluoxetine (CHEBI:5118) has role analgesic (CHEBI:35480) |
| fluoxetine (CHEBI:5118) has role antidepressant (CHEBI:35469) |
| fluoxetine (CHEBI:5118) has role drug allergen (CHEBI:88188) |
| fluoxetine (CHEBI:5118) has role environmental contaminant (CHEBI:78298) |
| fluoxetine (CHEBI:5118) has role serotonin uptake inhibitor (CHEBI:50949) |
| fluoxetine (CHEBI:5118) has role xenobiotic (CHEBI:35703) |
| fluoxetine (CHEBI:5118) is a racemate (CHEBI:60911) |
| IUPAC Name |
|---|
| rac-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine |
| INNs | Source |
|---|---|
| fluoxetina | ChemIDplus |
| fluoxetine | KEGG DRUG |
| fluoxétine | WHO MedNet |
| fluoxetinum | ChemIDplus |
| Synonyms | Source |
|---|---|
| (±)-N-methyl-3-phenyl-3-((α,α,α-trifluoro-p-tolyl)oxy)propylamine | ChemIDplus |
| (±)-N-methyl-γ-(4-(trifluoromethyl)phenoxy)benzenepropanamine | ChemIDplus |
| Brand Name | Source |
|---|---|
| Prozac | DrugBank |
| Manual Xrefs | Databases |
|---|---|
| D00326 | KEGG DRUG |
| DB00472 | DrugBank |
| DE2500110 | Patent |
| Fluoxetine | Wikipedia |
| HMDB0014615 | HMDB |
| US4314081 | Patent |
| Registry Numbers | Sources |
|---|---|
| Reaxys:3991406 | Reaxys |
| Beilstein:39914106 | Beilstein |
| CAS:54910-89-3 | KEGG DRUG |
| CAS:54910-89-3 | ChemIDplus |
| Citations |
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