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CHEBI:5118 - fluoxetine
| ChEBI ID | CHEBI:5118 |
| ChEBI Name | fluoxetine |
| Stars | |
| Definition | A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder. |
| Last Modified | 22 February 2017 |
| Formula | C17H18F3NO |
| Net Charge | 0 |
| Average Mass | 309.326 |
| Monoisotopic Mass | 309.13405 |
| Wikipedia |
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| Roles Classification |
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| Chemical Role: | environmental contaminant Any minor or unwanted substance introduced into the environment that can have undesired effects. |
| Biological Roles: | xenobiotic A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. drug allergen Any drug which causes the onset of an allergic reaction. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. |
| Applications: | serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. drug allergen Any drug which causes the onset of an allergic reaction. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| fluoxetine (CHEBI:5118) has functional parent (trifluoromethyl)benzene (CHEBI:36810) |
| fluoxetine (CHEBI:5118) has part (R)-fluoxetine (CHEBI:86991) |
| fluoxetine (CHEBI:5118) has part (S)-fluoxetine (CHEBI:86992) |
| fluoxetine (CHEBI:5118) has role analgesic (CHEBI:35480) |
| fluoxetine (CHEBI:5118) has role antidepressant (CHEBI:35469) |
| fluoxetine (CHEBI:5118) has role drug allergen (CHEBI:88188) |
| fluoxetine (CHEBI:5118) has role environmental contaminant (CHEBI:78298) |
| fluoxetine (CHEBI:5118) has role serotonin uptake inhibitor (CHEBI:50949) |
| fluoxetine (CHEBI:5118) has role xenobiotic (CHEBI:35703) |
| fluoxetine (CHEBI:5118) is a racemate (CHEBI:60911) |
| IUPAC Name |
|---|
| rac-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine |
| INNs | Source |
|---|---|
| fluoxetina | ChemIDplus |
| fluoxetine | KEGG DRUG |
| fluoxétine | WHO MedNet |
| fluoxetinum | ChemIDplus |
| Synonyms | Source |
|---|---|
| (±)-N-methyl-3-phenyl-3-((α,α,α-trifluoro-p-tolyl)oxy)propylamine | ChemIDplus |
| (±)-N-methyl-γ-(4-(trifluoromethyl)phenoxy)benzenepropanamine | ChemIDplus |
| Brand Name | Source |
|---|---|
| Prozac | DrugBank |
| Manual Xrefs | Databases |
|---|---|
| D00326 | KEGG DRUG |
| DB00472 | DrugBank |
| DE2500110 | Patent |
| Fluoxetine | Wikipedia |
| HMDB0014615 | HMDB |
| US4314081 | Patent |
| Registry Numbers | Sources |
|---|---|
| Reaxys:3991406 | Reaxys |
| Beilstein:39914106 | Beilstein |
| CAS:54910-89-3 | KEGG DRUG |
| CAS:54910-89-3 | ChemIDplus |
| Citations |
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