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CHEBI:51141 - alfuzosin
| Formula | C19H27N5O4 |
| Net Charge | 0 |
| Average Mass | 389.456 |
| Monoisotopic Mass | 389.20630 |
| SMILES | COc1cc2nc(N(C)CCCNC(=O)C3CCCO3)nc(N)c2cc1OC |
| InChI | InChI=1S/C19H27N5O4/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23) |
| InChIKey | WNMJYKCGWZFFKR-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. |
| Applications: | laxative An agent that produces a soft formed stool, and relaxes and loosens the bowels, typically used over a protracted period, to relieve constipation. Compare with cathartic, which is a substance that accelerates defecation. A substances can be both a laxative and a cathartic. alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| alfuzosin (CHEBI:51141) has role antihypertensive agent (CHEBI:35674) |
| alfuzosin (CHEBI:51141) has role antineoplastic agent (CHEBI:35610) |
| alfuzosin (CHEBI:51141) has role immunosuppressive agent (CHEBI:35705) |
| alfuzosin (CHEBI:51141) has role laxative (CHEBI:50503) |
| alfuzosin (CHEBI:51141) has role α-adrenergic antagonist (CHEBI:37890) |
| alfuzosin (CHEBI:51141) is a monocarboxylic acid amide (CHEBI:29347) |
| alfuzosin (CHEBI:51141) is a quinazolines (CHEBI:38530) |
| alfuzosin (CHEBI:51141) is a tetrahydrofuranol (CHEBI:47017) |
| Incoming Relation(s) |
| alfuzosin hydrochloride (CHEBI:32286) has part alfuzosin (CHEBI:51141) |
| IUPAC Name |
|---|
| N-{3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino]propyl}tetrahydrofuran-2-carboxamide |
| INNs | Source |
|---|---|
| alfuzosin | WHO MedNet |
| alfuzosina | WHO MedNet |
| alfuzosine | WHO MedNet |
| alfuzosinum | WHO MedNet |
| Synonym | Source |
|---|---|
| NSC-760065 | ChEMBL |
| Citations |
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