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CHEBI:49852 - 5,6-dichloro-1-β-D-ribofuranosyl-1H-benzimidazole

ChEBI IDCHEBI:49852
ChEBI Name5,6-dichloro-1-β-D-ribofuranosyl-1H-benzimidazole
Stars
ASCII Name5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole
DefinitionA 1-ribosylbenzimidazole that is 5,6-dichloro-1H-benzimidazole attached to a β-D-ribofuranosyl residue at position 1 via a glycosidic (N-glycosyl) linkage. It is an inhibitor for RNA polymerase II transcription.
Secondary ChEBI IDCHEBI:232947
Last Modified23 January 2025
SubmitterFlyBase
DownloadsMolfile
FormulaC12H12Cl2N2O4
Net Charge0
Average Mass319.144
Monoisotopic Mass318.01741
SMILESOC[C@H]1O[C@@H](n2cnc3cc(Cl)c(Cl)cc32)[C@H](O)[C@@H]1O
InChIInChI=1S/C12H12Cl2N2O4/c13-5-1-7-8(2-6(5)14)16(4-15-7)12-11(19)10(18)9(3-17)20-12/h1-2,4,9-12,17-19H,3H2/t9-,10-,11-,12-/m1/s1
InChIKeyXHSQDZXAVJRBMX-DDHJBXDOSA-N
Wikipedia
Roles Classification
Biological Roles:
apoptosis inducer  Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
EC 2.7.7.6 (RNA polymerase) inhibitor  An EC 2.7.7.* (nucleotidyltransferase) inhibitor that interferes with the action of RNA polymerase (EC 2.7.7.6).
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
5,6-dichloro-1-β-D-ribofuranosyl-1H-benzimidazole (CHEBI:49852) has role antineoplastic agent (CHEBI:35610)
5,6-dichloro-1-β-D-ribofuranosyl-1H-benzimidazole (CHEBI:49852) has role apoptosis inducer (CHEBI:68495)
5,6-dichloro-1-β-D-ribofuranosyl-1H-benzimidazole (CHEBI:49852) has role EC 2.7.7.6 (RNA polymerase) inhibitor (CHEBI:37416)
5,6-dichloro-1-β-D-ribofuranosyl-1H-benzimidazole (CHEBI:49852) is a 1-ribosylbenzimidazole (CHEBI:47917)
5,6-dichloro-1-β-D-ribofuranosyl-1H-benzimidazole (CHEBI:49852) is a organochlorine compound (CHEBI:36683)
IUPAC Name 
5,6-dichloro-1-β-D-ribofuranosyl-1H-benzimidazole
Synonyms  Source
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazolePDBeChem
5,6-dichloro-1-β-D-ribofuranosylbenzimidazoleChEBI
5,6-dichlororibofuranosylbenzimidazoleChEBI
5,6-dichloro-1-(β-D-ribofuranosyl)benzimidazoleChEBI
1-β-D-ribofuranosyl-5,6-dichlorobenzimidazoleChEBI
5,6-dichlorobenzimidazole 1-β-D-ribofuranosideChEBI
Manual XrefsDatabases
RFZPDBeChem
HMDB0242505HMDB
DB08473DrugBank
5,6-Dichloro-1-%CE%B2-D-ribofuranosylbenzimidazoleWikipedia
Registry NumbersSources
Reaxys:39123Reaxys
CAS:53-85-0ChEBI
Citations