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CHEBI:47619 - piclamilast

ChEBI IDCHEBI:47619
ChEBI Namepiclamilast
Stars
DefinitionA monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 3-(cyclopentyloxy)-4-methoxybenzoic acid with the primary amino group of 3,5-dichloropyridin-4-amine.
Last Modified19 March 2014
DownloadsMolfile
FormulaC18H18Cl2N2O3
Net Charge0
Average Mass381.259
Monoisotopic Mass380.06945
SMILESCOc1ccc(C(=O)Nc2c(Cl)cncc2Cl)cc1OC1CCCC1
InChIInChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23)
InChIKeyRRRUXBQSQLKHEL-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
phosphodiesterase IV inhibitor  An EC 3.1.4.53 (3',5'-cyclic-AMP phosphodiesterase) inhibitor that specifically blocks the action of phosphodiesterase IV.
Applications:
bronchodilator agent  An agent that causes an increase in the expansion of a bronchus or bronchial tubes.
anti-asthmatic drug  A drug used to treat asthma.
anti-inflammatory agent  Any compound that has anti-inflammatory effects.
ChEBI Ontology
Outgoing Relation(s)
piclamilast (CHEBI:47619) has role anti-asthmatic drug (CHEBI:49167)
piclamilast (CHEBI:47619) has role anti-inflammatory agent (CHEBI:67079)
piclamilast (CHEBI:47619) has role bronchodilator agent (CHEBI:35523)
piclamilast (CHEBI:47619) has role phosphodiesterase IV inhibitor (CHEBI:68844)
piclamilast (CHEBI:47619) is a aromatic ether (CHEBI:35618)
piclamilast (CHEBI:47619) is a benzamides (CHEBI:22702)
piclamilast (CHEBI:47619) is a chloropyridine (CHEBI:39173)
piclamilast (CHEBI:47619) is a monocarboxylic acid amide (CHEBI:29347)
IUPAC Name 
3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-methoxybenzamide
INNs  Source
piclamilastumWHO MedNet
piclamilastWHO MedNet
piclamilastWHO MedNet
piclamilastWHO MedNet
Synonyms  Source
3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridinyl)-4-methoxybenzamideChemIDplus
RP 73-401ChemIDplus
3-(cyclopentyloxy)-N-(3,5-dichloro-4-pyridyl)-p-anisamideChemIDplus
RP-73-401ChemIDplus
RP 73401ChemIDplus
Manual XrefsDatabases
PILPDBeChem
PiclamilastWikipedia
D05474KEGG DRUG
DB01791DrugBank
Registry NumbersSources
Reaxys:6937319Reaxys
CAS:144035-83-6ChemIDplus
Citations