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CHEBI:4759 - edrophonium chloride

ChEBI IDCHEBI:4759
ChEBI Nameedrophonium chloride
Stars
DefinitionThe chloride salt of edrophonium. A reversible inhibitor of cholinesterase with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes), it is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.
Secondary ChEBI IDCHEBI:267875
Last Modified26 July 2010
DownloadsMolfile
FormulaC10H16NO.Cl
Net Charge0
Average Mass201.697
Monoisotopic Mass201.09204
SMILESCC[N+](C)(C)c1cccc(O)c1.[Cl-]
InChIInChI=1S/C10H15NO.ClH/c1-4-11(2,3)9-6-5-7-10(12)8-9;/h5-8H,4H2,1-3H3;1H
InChIKeyBXKDSDJJOVIHMX-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
EC 3.1.1.8 (cholinesterase) inhibitor  An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of cholinesterase (EC 3.1.1.8).
Applications:
diagnostic agent  A substance administered to aid diagnosis of a disease.
antidote  Any protective agent counteracting or neutralizing the action of poisons.
ChEBI Ontology
Outgoing Relation(s)
edrophonium chloride (CHEBI:4759) has part edrophonium (CHEBI:251408)
edrophonium chloride (CHEBI:4759) has role antidote (CHEBI:50247)
edrophonium chloride (CHEBI:4759) has role diagnostic agent (CHEBI:33295)
edrophonium chloride (CHEBI:4759) has role EC 3.1.1.8 (cholinesterase) inhibitor (CHEBI:37733)
edrophonium chloride (CHEBI:4759) is a chloride salt (CHEBI:23114)
edrophonium chloride (CHEBI:4759) is a quaternary ammonium salt (CHEBI:35273)
IUPAC Name 
N-ethyl-3-hydroxy-N,N-dimethylanilinium chloride
INNs  Source
cloruro de edrofonioChemIDplus
edrophonii chloridumChemIDplus
chlorure d'edrophoniumChemIDplus
edrophonium chlorideChemIDplus
Synonyms  Source
EDROPHONIUM CHLORIDEChEMBL
ethyl(m-hydroxyphenyl)dimethylammonium chlorideChemIDplus
N-ethyl-3-hydroxy-N,N-dimethylbenzenaminium chlorideChEBI
(3-hydroxyphenyl)dimethylethylammonium chlorideChEBI
3-hydroxy-N,N-dimethyl-N-ethylanilinium chlorideChEBI
Manual XrefsDatabases
D00994KEGG DRUG
US2647924Patent
DB01010DrugBank
EdrophoniumWikipedia
Registry NumbersSources
Beilstein:3748734Beilstein
CAS:116-38-1KEGG DRUG
CAS:116-38-1ChemIDplus
CAS:116-38-1NIST Chemistry WebBook
Citations