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CHEBI:47532 - licofelone
| Formula | C23H22ClNO2 |
| Net Charge | 0 |
| Average Mass | 379.887 |
| Monoisotopic Mass | 379.13391 |
| SMILES | CC1(C)Cc2c(-c3ccccc3)c(-c3ccc(Cl)cc3)c(CC(=O)O)n2C1 |
| InChI | InChI=1S/C23H22ClNO2/c1-23(2)13-19-22(15-6-4-3-5-7-15)21(16-8-10-17(24)11-9-16)18(12-20(26)27)25(19)14-23/h3-11H,12-14H2,1-2H3,(H,26,27) |
| InChIKey | UAWXGRJVZSAUSZ-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Roles Classification |
|---|
| Chemical Role: | Bronsted acid A molecular entity capable of donating a hydron to an acceptor (Brønsted base). |
| Biological Roles: | EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor A lipoxygenase inhibitor that interferes with the action of arachidonate 5-lipoxygenase (EC 1.13.11.34). analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes. |
| Applications: | analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders. anticonvulsant A drug used to prevent seizures or reduce their severity. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. non-steroidal anti-inflammatory drug An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| licofelone (CHEBI:47532) has role analgesic (CHEBI:35480) |
| licofelone (CHEBI:47532) has role anticonvulsant (CHEBI:35623) |
| licofelone (CHEBI:47532) has role antineoplastic agent (CHEBI:35610) |
| licofelone (CHEBI:47532) has role EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor (CHEBI:64964) |
| licofelone (CHEBI:47532) has role EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (CHEBI:35544) |
| licofelone (CHEBI:47532) has role neuroprotective agent (CHEBI:63726) |
| licofelone (CHEBI:47532) has role non-steroidal anti-inflammatory drug (CHEBI:35475) |
| licofelone (CHEBI:47532) is a monocarboxylic acid (CHEBI:25384) |
| licofelone (CHEBI:47532) is a monochlorobenzenes (CHEBI:83403) |
| licofelone (CHEBI:47532) is a pyrrolizines (CHEBI:38522) |
| IUPAC Name |
|---|
| [6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid |
| INNs | Source |
|---|---|
| licofelona | WHO MedNet |
| licofelone | WHO MedNet |
| licofélone | WHO MedNet |
| licofelonum | WHO MedNet |
| Synonyms | Source |
|---|---|
| [2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl]acetic acid | ChEBI |
| 6-(4-chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizine-5-acetic acid | ChEBI |
| ML 3000 | DrugBank |
| ML-3000 | DrugBank |
| ML3000 | DrugBank |
| Manual Xrefs | Databases |
|---|---|
| CZ20080621 | Patent |
| DB04725 | DrugBank |
| HMDB0254080 | HMDB |
| LCF | PDBeChem |
| Licofelone | Wikipedia |
| Registry Numbers | Sources |
|---|---|
| CAS:156897-06-2 | DrugBank |
| Citations |
|---|