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CHEBI:4696 - donepezil hydrochloride

ChEBI IDCHEBI:4696
ChEBI Namedonepezil hydrochloride
Stars
DefinitionA racemate comprising equimolar amounts of (R)- and (S)- donepezil hydrochloride. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
Last Modified26 November 2019
FormulaC24H29NO3.HCl
Net Charge0
Average Mass415.960
Monoisotopic Mass415.19142
Roles Classification
Biological Role:
EC 3.1.1.7 (acetylcholinesterase) inhibitor  An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of enzyme acetylcholinesterase (EC 3.1.1.7), which helps breaking down of acetylcholine into choline and acetic acid.
ChEBI Ontology
Outgoing Relation(s)
donepezil hydrochloride (CHEBI:4696) has part (R)-donepezil hydrochloride (CHEBI:145504)
donepezil hydrochloride (CHEBI:4696) has part (S)-donepezil hydrochloride (CHEBI:145505)
donepezil hydrochloride (CHEBI:4696) has role EC 3.1.1.7 (acetylcholinesterase) inhibitor (CHEBI:38462)
donepezil hydrochloride (CHEBI:4696) is a racemate (CHEBI:60911)
IUPAC Names 
rac-1-benzyl-4-[(5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl]piperidinium chloride
rac-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one hydrochloride
Synonyms  Source
(+-)-2-((1-Benzyl-4-piperidyl)methyl)-5,6-dimethoxy-1-indanone hydrochlorideChemIDplus
1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine hclChemIDplus
Donepezil HClChemIDplus
Manual XrefsDatabases
D00670KEGG DRUG
DB00843DrugBank
Registry NumbersSources
Beilstein:7062905Beilstein
CAS:120011-70-3KEGG DRUG
CAS:120011-70-3ChemIDplus