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CHEBI:4696 - donepezil hydrochloride
| ChEBI ID | CHEBI:4696 |
| ChEBI Name | donepezil hydrochloride |
| Stars | |
| Definition | A racemate comprising equimolar amounts of (R)- and (S)- donepezil hydrochloride. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. |
| Last Modified | 26 November 2019 |
| Formula | C24H29NO3.HCl |
| Net Charge | 0 |
| Average Mass | 415.960 |
| Monoisotopic Mass | 415.19142 |
| Roles Classification |
|---|
| Biological Role: | EC 3.1.1.7 (acetylcholinesterase) inhibitor An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of enzyme acetylcholinesterase (EC 3.1.1.7), which helps breaking down of acetylcholine into choline and acetic acid. |
| Applications: | antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| donepezil hydrochloride (CHEBI:4696) has part (R)-donepezil hydrochloride (CHEBI:145504) |
| donepezil hydrochloride (CHEBI:4696) has part (S)-donepezil hydrochloride (CHEBI:145505) |
| donepezil hydrochloride (CHEBI:4696) has role antidepressant (CHEBI:35469) |
| donepezil hydrochloride (CHEBI:4696) has role antineoplastic agent (CHEBI:35610) |
| donepezil hydrochloride (CHEBI:4696) has role EC 3.1.1.7 (acetylcholinesterase) inhibitor (CHEBI:38462) |
| donepezil hydrochloride (CHEBI:4696) is a racemate (CHEBI:60911) |
| IUPAC Names |
|---|
| rac-1-benzyl-4-[(5,6-dimethoxy-1-oxo-2,3-dihydro-1H-inden-2-yl)methyl]piperidinium chloride |
| rac-2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one hydrochloride |
| Synonyms | Source |
|---|---|
| 1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine hcl | ChemIDplus |
| (+-)-2-((1-Benzyl-4-piperidyl)methyl)-5,6-dimethoxy-1-indanone hydrochloride | ChemIDplus |
| Adlarity | ChEMBL |
| BNAG | ChEMBL |
| Donepezil HCl | ChemIDplus |
| NSC-737535 | ChEMBL |
| Brand Names | Source |
|---|---|
| Aricept evess | ChEMBL |
| Aricept odt | ChEMBL |
| Donepezil hydrochloride component of namzaric | ChEMBL |
| Registry Numbers | Sources |
|---|---|
| Beilstein:7062905 | Beilstein |
| CAS:120011-70-3 | KEGG DRUG |
| CAS:120011-70-3 | ChemIDplus |
| Citations |
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