CHEBI:4653 - dipyridamole

ChEBI IDCHEBI:4653
ChEBI Namedipyridamole
Stars
DefinitionA pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.
Last Modified22 February 2017
DownloadsMolfile
FormulaC24H40N8O4
Net Charge0
Average Mass504.636
Monoisotopic Mass504.31725
SMILESOCCN(CCO)c1nc(N2CCCCC2)c2nc(N(CCO)CCO)nc(N3CCCCC3)c2n1
InChIInChI=1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
InChIKeyIZEKFCXSFNUWAM-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
anti-HIV agent  An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus.
EC 3.5.4.4 (adenosine deaminase) inhibitor  An EC 3.5.4.* (non-peptide cyclic amidine C-N hydrolase) inhibitor that interferes with the action of adenosine deaminase (EC 3.5.4.4).
antiviral agent  A substance that destroys or inhibits replication of viruses.
Applications:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
antirheumatic drug  A drug used to treat rheumatoid arthritis.
anti-anaemic agent  A compound which increases either the number of red cells or the amount of haemoglobin in the blood.
anticoagulant  An agent that prevents blood clotting.
cardiovascular drug  A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
vasodilator agent  A drug used to cause dilation of the blood vessels.
platelet aggregation inhibitor  A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
ChEBI Ontology
Outgoing Relation(s)
dipyridamole (CHEBI:4653) has role adenosine phosphodiesterase inhibitor (CHEBI:50444)
dipyridamole (CHEBI:4653) has role anti-anaemic agent (CHEBI:75835)
dipyridamole (CHEBI:4653) has role anti-HIV agent (CHEBI:64946)
dipyridamole (CHEBI:4653) has role anticoagulant (CHEBI:50249)
dipyridamole (CHEBI:4653) has role antihypertensive agent (CHEBI:35674)
dipyridamole (CHEBI:4653) has role antineoplastic agent (CHEBI:35610)
dipyridamole (CHEBI:4653) has role antirheumatic drug (CHEBI:35842)
dipyridamole (CHEBI:4653) has role antiviral agent (CHEBI:22587)
dipyridamole (CHEBI:4653) has role cardiovascular drug (CHEBI:35554)
dipyridamole (CHEBI:4653) has role EC 3.5.4.4 (adenosine deaminase) inhibitor (CHEBI:50445)
dipyridamole (CHEBI:4653) has role platelet aggregation inhibitor (CHEBI:50427)
dipyridamole (CHEBI:4653) has role vasodilator agent (CHEBI:35620)
dipyridamole (CHEBI:4653) is a piperidines (CHEBI:26151)
dipyridamole (CHEBI:4653) is a pyrimidopyrimidine (CHEBI:48514)
dipyridamole (CHEBI:4653) is a tertiary amino compound (CHEBI:50996)
dipyridamole (CHEBI:4653) is a tetrol (CHEBI:33573)
IUPAC Name 
2,2',2'',2'''-[(4,8-dipiperidin-1-ylpyrimido[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol
INNs  Source
dipyridamoleChemIDplus
dipyridamolumChemIDplus
Synonyms  Source
B01AC07ChEMBL
DipyridamineDrugBank
DipyudamineDrugBank
DypyridamolDrugBank
NSC-515776ChEMBL
RA-8ChEMBL
Brand Names  Source
AttiaChEMBL
CardoxinChEBI
Cerebrovase 100ChEMBL
Cerebrovase 25ChEMBL
Cleridium 150DrugBank
CurantylDrugBank
Manual XrefsDatabases
924DrugCentral
D00302KEGG DRUG
DB00975DrugBank
DipyridamoleWikipedia
GB807826Patent
LSM-3927LINCS
US3031450Patent
Registry NumbersSources
Beilstein:0068373Beilstein
Reaxys:68373Reaxys
CAS:58-32-2ChemIDplus
Citations