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CHEBI:45906 - suramin
| Formula | C51H40N6O23S6 |
| Net Charge | 0 |
| Average Mass | 1297.302 |
| Monoisotopic Mass | 1296.04691 |
| SMILES | Cc1ccc(C(=O)Nc2ccc(S(=O)(=O)O)c3cc(S(=O)(=O)O)cc(S(=O)(=O)O)c23)cc1NC(=O)c1cccc(NC(=O)Nc2cccc(C(=O)Nc3cc(C(=O)Nc4ccc(S(=O)(=O)O)c5cc(S(=O)(=O)O)cc(S(=O)(=O)O)c45)ccc3C)c2)c1 |
| InChI | InChI=1S/C51H40N6O23S6/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80) |
| InChIKey | FIAFUQMPZJWCLV-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | purinergic receptor P2 antagonist An antagonist at purinergic P2 receptors EC 2.7.11.13 (protein kinase C) inhibitor An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of protein kinase C (EC 2.7.11.13). GABA antagonist A compound that inhibits the action of γ-aminobutyric acid. apoptosis inhibitor Any substance that inhibits the process of apoptosis (programmed cell death) in multi-celled organisms. trypanocidal drug A drug used to treat or prevent infections caused by protozoal organisms belonging to the suborder Trypanosomatida. ryanodine receptor agonist A ryanodine receptor modulator which activates the receptor. Ryanodine receptors (RyRs) act as selective ion channels, modulating the release of calcium. Activating the receptors causes the release of calcium, so depleting internal calcium and ultimately preventing further muscle contraction. |
| Applications: | angiogenesis inhibitor An agent and endogenous substances that antagonize or inhibit the development of new blood vessels. antinematodal drug A substance used in the treatment or control of nematode infestations. GABA antagonist A compound that inhibits the action of γ-aminobutyric acid. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. trypanocidal drug A drug used to treat or prevent infections caused by protozoal organisms belonging to the suborder Trypanosomatida. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| suramin (CHEBI:45906) has functional parent naphthalene-1,3,5-trisulfonic acid (CHEBI:36334) |
| suramin (CHEBI:45906) has role angiogenesis inhibitor (CHEBI:48422) |
| suramin (CHEBI:45906) has role antinematodal drug (CHEBI:35444) |
| suramin (CHEBI:45906) has role antineoplastic agent (CHEBI:35610) |
| suramin (CHEBI:45906) has role apoptosis inhibitor (CHEBI:68494) |
| suramin (CHEBI:45906) has role EC 2.7.11.13 (protein kinase C) inhibitor (CHEBI:37700) |
| suramin (CHEBI:45906) has role GABA antagonist (CHEBI:65259) |
| suramin (CHEBI:45906) has role GABA-gated chloride channel antagonist (CHEBI:38999) |
| suramin (CHEBI:45906) has role purinergic receptor P2 antagonist (CHEBI:91079) |
| suramin (CHEBI:45906) has role ryanodine receptor agonist (CHEBI:67114) |
| suramin (CHEBI:45906) has role trypanocidal drug (CHEBI:36335) |
| suramin (CHEBI:45906) is a naphthalenesulfonic acid (CHEBI:36336) |
| suramin (CHEBI:45906) is a phenylureas (CHEBI:134043) |
| suramin (CHEBI:45906) is a secondary carboxamide (CHEBI:140325) |
| suramin (CHEBI:45906) is conjugate acid of suramin(6−) (CHEBI:180911) |
| Incoming Relation(s) |
| suramin(6−) (CHEBI:180911) is conjugate base of suramin (CHEBI:45906) |
| IUPAC Name |
|---|
| 8,8'-{carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]}dinaphthalene-1,3,5-trisulfonic acid |
| Synonyms | Source |
|---|---|
| 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFONIC ACID | PDBeChem |
| Belganyl | ChemIDplus |
| Naganol | ChemIDplus |
| Naphuride | ChemIDplus |
| Suramin | KEGG COMPOUND |
| Citations |
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