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CHEBI:4495 - diazoxide

ChEBI IDCHEBI:4495
ChEBI Namediazoxide
Stars
DefinitionA benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the β- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Secondary ChEBI IDCHEBI:6046
Last Modified19 June 2018
DownloadsMolfile
FormulaC8H7ClN2O2S
Net Charge0
Average Mass230.676
Monoisotopic Mass229.99168
SMILESCC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
InChIInChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
InChIKeyGDLBFKVLRPITMI-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
sympathomimetic agent  A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
sodium channel blocker  An agent that inhibits sodium influx through cell membranes.
beta-adrenergic agonist  An agent that selectively binds to and activates β-adrenergic receptors.
K-ATP channel agonist  A compound which acts as an agonist at the ATP-sensitive K+ channel.
Applications:
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
sympathomimetic agent  A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
cardiotonic drug  A drug that has a strengthening effect on the heart or that can increase cardiac output.
vasodilator agent  A drug used to cause dilation of the blood vessels.
bronchodilator agent  An agent that causes an increase in the expansion of a bronchus or bronchial tubes.
diuretic  An agent that promotes the excretion of urine through its effects on kidney function.
beta-adrenergic agonist  An agent that selectively binds to and activates β-adrenergic receptors.
ChEBI Ontology
Outgoing Relation(s)
diazoxide (CHEBI:4495) has role antihypertensive agent (CHEBI:35674)
diazoxide (CHEBI:4495) has role bronchodilator agent (CHEBI:35523)
diazoxide (CHEBI:4495) has role cardiotonic drug (CHEBI:38147)
diazoxide (CHEBI:4495) has role diuretic (CHEBI:35498)
diazoxide (CHEBI:4495) has role K-ATP channel agonist (CHEBI:64338)
diazoxide (CHEBI:4495) has role sodium channel blocker (CHEBI:38633)
diazoxide (CHEBI:4495) has role sympathomimetic agent (CHEBI:35524)
diazoxide (CHEBI:4495) has role vasodilator agent (CHEBI:35620)
diazoxide (CHEBI:4495) has role β-adrenergic agonist (CHEBI:35522)
diazoxide (CHEBI:4495) is a benzothiadiazine (CHEBI:50265)
diazoxide (CHEBI:4495) is a organochlorine compound (CHEBI:36683)
diazoxide (CHEBI:4495) is a sulfone (CHEBI:35850)
IUPAC Name 
7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
INNs  Source
diazoxideChemIDplus
diazoxidoChemIDplus
diazoxidumChemIDplus
Synonyms  Source
DiazoxideKEGG COMPOUND
DiazossidoChemIDplus
Brand Name  Source
EudemineDrugBank
Manual XrefsDatabases
C06949KEGG COMPOUND
DB01119DrugBank
D00294KEGG DRUG
US2986573Patent
US3345365Patent
DE723278Patent
DiazoxideWikipedia
HMDB0015251HMDB
LSM-3639LINCS
854DrugCentral
Registry NumbersSources
Reaxys:523907Reaxys
CAS:364-98-7ChemIDplus
Citations