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CHEBI:43871 - fasudil

ChEBI IDCHEBI:43871
ChEBI Namefasudil
Stars
DefinitionAn isoquinoline substituted by a (1,4-diazepan-1-yl)sulfonyl group at position 5. It is a Rho-kinase inhibitor and its hydrochloride hydrate form is approved for the treatment of cerebral vasospasm and cerebral ischemia.
Last Modified8 October 2021
DownloadsMolfile
FormulaC14H17N3O2S
Net Charge0
Average Mass291.376
Monoisotopic Mass291.10415
SMILESO=S(=O)(c1cccc2cnccc12)N1CCCNCC1
InChIInChI=1S/C14H17N3O2S/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14/h1,3-5,7,11,15H,2,6,8-10H2
InChIKeyNGOGFTYYXHNFQH-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
calcium channel blocker  One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools.
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor  An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.
Applications:
geroprotector  Any compound that supports healthy aging, slows the biological aging process, or extends lifespan.
neuroprotective agent  Any compound that can be used for the treatment of neurodegenerative disorders.
vasodilator agent  A drug used to cause dilation of the blood vessels.
nootropic agent  Any compound that improves mental functions such as cognition, memory, intelligence, motivation, attention, and concentration.
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
ChEBI Ontology
Outgoing Relation(s)
fasudil (CHEBI:43871) has role antihypertensive agent (CHEBI:35674)
fasudil (CHEBI:43871) has role calcium channel blocker (CHEBI:38215)
fasudil (CHEBI:43871) has role EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor (CHEBI:50925)
fasudil (CHEBI:43871) has role geroprotector (CHEBI:176497)
fasudil (CHEBI:43871) has role neuroprotective agent (CHEBI:63726)
fasudil (CHEBI:43871) has role nootropic agent (CHEBI:66980)
fasudil (CHEBI:43871) has role vasodilator agent (CHEBI:35620)
fasudil (CHEBI:43871) is a N-sulfonyldiazepane (CHEBI:46946)
fasudil (CHEBI:43871) is a isoquinolines (CHEBI:24922)
fasudil (CHEBI:43871) is conjugate base of fasudil(1+) (CHEBI:180694)
Incoming Relation(s)
fasudil(1+) (CHEBI:180694) is conjugate acid of fasudil (CHEBI:43871)
IUPAC Name 
5-(1,4-diazepan-1-ylsulfonyl)isoquinoline
INNs  Source
fasudilWHO MedNet
fasudilumWHO MedNet
fasudilWHO MedNet
fasudilWHO MedNet
Synonyms  Source
5-[(hexahydro-1H-1,4-diazepin-1-yl)sulfonyl]isoquinolineChEBI
HA-1077DrugCentral
HA1077ChemIDplus
HA 1077ChemIDplus
AT 877ChemIDplus
AT-877ChemIDplus
Manual XrefsDatabases
M77PDBeChem
LSM-3715LINCS
1132DrugCentral
3426ChemSpider
DB08162DrugBank
HMDB0252175HMDB
D07941KEGG DRUG
FasudilWikipedia
Registry NumbersSources
CAS:103745-39-7ChemIDplus
Citations