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CHEBI:43572 - kojic acid
| Formula | C6H6O4 |
| Net Charge | 0 |
| Average Mass | 142.110 |
| Monoisotopic Mass | 142.02661 |
| SMILES | O=c1cc(CO)occ1O |
| InChI | InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2 |
| InChIKey | BEJNERDRQOWKJM-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Aspergillus oryzae (ncbitaxon:5062) | - | PubMed (24116376) |
| Roles Classification |
|---|
| Biological Roles: | EC 1.10.3.2 (laccase) inhibitor Any EC 1.10.3.* (oxidoreductase acting on diphenols and related substances as donors with oxygen as acceptor) inhibitor that interferes with the action of laccase (EC 1.10.3.2). NF-kappaB inhibitor An inhibitor of NF-κB (nuclear factor κ-light-chain-enhancer of activated B cells), a protein complex involved in the transcription of DNA. EC 1.14.18.1 (tyrosinase) inhibitor Any EC 1.14.18.* (oxidoreductase acting on paired donors, miscellaneous compound as one donor, incorporating 1 atom of oxygen) inhibitor that interferes with the action of tyrosinase (monophenol monooxygenase), EC 1.14.18.1, an enzyme that catalyses the oxidation of phenols (such as tyrosine) and is widespread in plants and animals. EC 1.4.3.3 (D-amino-acid oxidase) inhibitor Any EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor that interferes with the action of D-amino-acid oxidase (EC 1.4.3.3). Aspergillus metabolite Any fungal metabolite produced during a metabolic reaction in the mould, Aspergillus . EC 1.10.3.1 (catechol oxidase) inhibitor Any EC 1.10.3.* (oxidoreductase acting on diphenols and related substances as donors with oxygen as acceptor) inhibitor that interferes with the action of catechol oxidase (EC 1.10.3.1). EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor Any EC 1.13.11.* (oxidoreductase acting on single donors and incorporating 2 O atoms) inhibitor that interferes with the action of quercetin 2,3-dioxygenase (EC 1.13.1.24). |
| Application: | skin lightening agent Any cosmetic used to lighten the colour of skin by reducing the concentration of melanin. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| kojic acid (CHEBI:43572) has parent hydride 4H-pyran (CHEBI:35593) |
| kojic acid (CHEBI:43572) has role Aspergillus metabolite (CHEBI:76956) |
| kojic acid (CHEBI:43572) has role EC 1.10.3.1 (catechol oxidase) inhibitor (CHEBI:85049) |
| kojic acid (CHEBI:43572) has role EC 1.10.3.2 (laccase) inhibitor (CHEBI:85050) |
| kojic acid (CHEBI:43572) has role EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor (CHEBI:85051) |
| kojic acid (CHEBI:43572) has role EC 1.14.18.1 (tyrosinase) inhibitor (CHEBI:59997) |
| kojic acid (CHEBI:43572) has role EC 1.4.3.3 (D-amino-acid oxidase) inhibitor (CHEBI:85052) |
| kojic acid (CHEBI:43572) has role NF-κB inhibitor (CHEBI:73240) |
| kojic acid (CHEBI:43572) has role skin lightening agent (CHEBI:85046) |
| kojic acid (CHEBI:43572) is a 4-pyranones (CHEBI:131906) |
| kojic acid (CHEBI:43572) is a enol (CHEBI:33823) |
| kojic acid (CHEBI:43572) is a primary alcohol (CHEBI:15734) |
| IUPAC Name |
|---|
| 5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one |
| Synonyms | Source |
|---|---|
| Kojic acid | KEGG COMPOUND |
| 5-Hydroxy-2-(hydroxymethyl)-4-pyrone | KEGG COMPOUND |
| 5-hydroxy-2-hydroxymethyl-4-pyrone | ChemIDplus |
| Kojisäure | ChEBI |
| ácido kójico | ChEBI |
| Manual Xrefs | Databases |
|---|---|
| C14516 | KEGG COMPOUND |
| KOJ | PDBeChem |
| DB01759 | DrugBank |
| KOJIC-ACID | MetaCyc |
| HMDB0032923 | HMDB |
| AU2012268879 | Patent |
| JP2013017408 | Patent |
| Kojic_acid | Wikipedia |
| 3977 | DrugCentral |
| Citations |
|---|