EMBL-EBI | Chemical Biology | ChEBI

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:40802 - 8-aminoguanine

ChEBI IDCHEBI:40802
ChEBI Name8-aminoguanine
Stars
DefinitionA member of the class of oxopurines that is guanine substituted by an amino group at position 8. It is a naturally occurring purine that has diuretic, natriuretic, glucosuric, antikaliuretic, and antihypertensive activity.
Last Modified4 February 2025
DownloadsMolfile
FormulaC5H6N6O
Net Charge0
Average Mass166.144
Monoisotopic Mass166.06031
SMILESNc1nc(=O)c2nc(N)nc2n1
InChIInChI=1S/C5H6N6O/c6-4-8-1-2(9-4)10-5(7)11-3(1)12/h(H6,6,7,8,9,10,11,12)
InChIKeyWYDKPTZGVLTYPG-UHFFFAOYSA-N
Roles Classification
Biological Roles:
Rac1 inhibitor  Any inhibitor of Rac1.
EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor  An EC 2.4.2.* (pentosyltransferase) inhibitor that interferes with the action of purine nucleoside phosphorylase (EC 2.4.2.1).
Applications:
diuretic  An agent that promotes the excretion of urine through its effects on kidney function.
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
ChEBI Ontology
Outgoing Relation(s)
8-aminoguanine (CHEBI:40802) has role antihypertensive agent (CHEBI:35674)
8-aminoguanine (CHEBI:40802) has role diuretic (CHEBI:35498)
8-aminoguanine (CHEBI:40802) has role EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor (CHEBI:63090)
8-aminoguanine (CHEBI:40802) has role Rac1 inhibitor (CHEBI:197347)
8-aminoguanine (CHEBI:40802) is a 2-aminopurines (CHEBI:20702)
8-aminoguanine (CHEBI:40802) is a 8-aminopurines (CHEBI:233444)
8-aminoguanine (CHEBI:40802) is a oxopurine (CHEBI:25810)
IUPAC Name 
2,8-diamino-1,9-dihydro-6H-purin-6-one
Synonyms  Source
8-AGChEBI
2,8-diamino-hypoxanthineChEBI
Manual XrefsDatabases
ANGPDBeChem
Registry NumbersSources
CAS:28128-41-8ChEBI
Citations