cosyntropin (CHEBI:3901)

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CHEBI:3901 - cosyntropin

ChEBI ID	CHEBI:3901
ChEBI Name	cosyntropin
Stars
Definition	A synthetic peptide that is identical to the 24-amino acid segment at the N-terminal of adrenocorticotropic hormone (corticotropin). A segment similar in all species, it contains the biological activity that stimulates production of corticosteroids in the adrenal cortex. It is used diagnostically to investigate adrenocortical insufficiency.
Last Modified	28 May 2024
Downloads	Molfile

Formula	C136H210N40O31S
Net Charge	0
Average Mass	2933.492
Monoisotopic Mass	2931.58064
SMILES	CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1cncn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1cnc2ccccc12)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C)C(C)C
InChI	InChI=1S/C136H210N40O31S/c1-75(2)109(127(200)154-71-106(181)156-88(31-13-17-52-137)114(187)158-89(32-14-18-53-138)115(188)159-91(35-21-56-149-134(142)143)116(189)164-96(37-23-58-151-136(146)147)131(204)175-60-25-39-104(175)126(199)173-111(77(5)6)128(201)163-90(33-15-19-54-139)120(193)171-110(76(3)4)129(202)169-101(65-80-43-47-84(180)48-44-80)132(205)176-61-26-40-105(176)133(206)207)172-125(198)103-38-24-59-174(103)130(203)95(34-16-20-55-140)157-107(182)70-153-113(186)99(66-81-68-152-87-30-12-11-29-85(81)87)167-117(190)92(36-22-57-150-135(144)145)160-121(194)98(63-78-27-9-8-10-28-78)166-123(196)100(67-82-69-148-74-155-82)168-118(191)93(49-50-108(183)184)161-119(192)94(51-62-208-7)162-124(197)102(73-178)170-122(195)97(165-112(185)86(141)72-177)64-79-41-45-83(179)46-42-79/h8-12,27-30,41-48,68-69,74-77,86,88-105,109-111,152,177-180H,13-26,31-40,49-67,70-73,137-141H2,1-7H3,(H,148,155)(H,153,186)(H,154,200)(H,156,181)(H,157,182)(H,158,187)(H,159,188)(H,160,194)(H,161,192)(H,162,197)(H,163,201)(H,164,189)(H,165,185)(H,166,196)(H,167,190)(H,168,191)(H,169,202)(H,170,195)(H,171,193)(H,172,198)(H,173,199)(H,183,184)(H,206,207)(H4,142,143,149)(H4,144,145,150)(H4,146,147,151)/t86-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,109-,110-,111-/m0/s1
InChIKey	ZOEFCCMDUURGSE-SQKVDDBVSA-N

Roles Classification

Chemical Role:

Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid).

Applications:

antispasmodic drug A drug that suppresses spasms. These are usually caused by smooth muscle contraction, especially in tubular organs. The effect is to prevent spasms of the stomach, intestine or urinary bladder.

diagnostic agent A substance administered to aid diagnosis of a disease.

antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.

nephroprotective agent Any protective agent that is able to prevent damage to the kidney.

ChEBI Ontology

Outgoing Relation(s)
	cosyntropin (CHEBI:3901) has role antihypertensive agent (CHEBI:35674)
	cosyntropin (CHEBI:3901) has role antispasmodic drug (CHEBI:53784)
	cosyntropin (CHEBI:3901) has role diagnostic agent (CHEBI:33295)
	cosyntropin (CHEBI:3901) has role nephroprotective agent (CHEBI:76595)
	cosyntropin (CHEBI:3901) is a polypeptide (CHEBI:15841)

IUPAC Name
L-seryl-L-tyrosyl-L-seryl-L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valylglycyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-prolyl-L-valyl-L-lysyl-L-valyl-L-tyrosyl-L-prolyline

INNs	Source
tetracosactida	WHO MedNet
tetracosactide	ChemIDplus

Synonyms	Source
adrenocorticotropic hormone 1-24	ChemIDplus
ATCH (1-24)	ChEBI
corticotropin-(1-24)	ChemIDplus
corticotropin-(1-24) tetracosapeptide	ChEBI
Corticotropin tetracosapeptide	ChEMBL
Cosyntropin	KEGG COMPOUND

Brand Names	Source
Cortrosyn	ChEMBL
Synacthen	ChEMBL
Synacthen depot	ChEMBL

Manual Xrefs	Databases
4516	DrugCentral
D00284	KEGG DRUG
DB01284	DrugBank

Registry Numbers	Sources
CAS:16960-16-0	ChemIDplus
CAS:16960-16-0	KEGG COMPOUND

Citations