astromicin (CHEBI:37923)

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CHEBI:37923 - astromicin

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ChEBI ID	CHEBI:37923
ChEBI Name	astromicin
Stars
Definition	An amino cyclitol glycoside that is L-chiro-inositol in which the hydroxy groups at positions 1, 4, and 6 are replaced by aminoacetyl)methylamino, amino, and methoxy groups, respectively, and in which the hydroxy group at position 3 is converted to the corresponding 2,6-diamino-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranoside. The major component of fortimicin, obtained from Micromonospora olivasterospora. It is administered (as the sulfate salt) by intramuscular injection or intravenous infusion for the treatment of severe systemic infections due to sensitive Gram-negative organisms.
Last Modified	22 February 2017
Downloads	Molfile

Formula	C17H35N5O6
Net Charge	0
Average Mass	405.496
Monoisotopic Mass	405.25873
SMILES	[H][C@@]1([C@H](C)N)CC[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)[C@H](O)[C@H](OC)[C@@H](N(C)C(=O)CN)[C@H]2O)O1
InChI	InChI=1S/C17H35N5O6/c1-7(19)9-5-4-8(20)17(27-9)28-15-11(21)13(24)16(26-3)12(14(15)25)22(2)10(23)6-18/h7-9,11-17,24-25H,4-6,18-21H2,1-3H3/t7-,8+,9-,11-,12-,13-,14+,15+,16+,17+/m0/s1
InChIKey	BIDUPMYXGFNAEJ-APGVDKLISA-N

Wikipedia

Roles Classification

Chemical Role:	Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:	antibacterial agent A substance (or active part thereof) that kills or slows the growth of bacteria. metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.

ChEBI Ontology

Outgoing Relation(s)
	astromicin (CHEBI:37923) has role antibacterial agent (CHEBI:33282)
	astromicin (CHEBI:37923) has role metabolite (CHEBI:25212)
	astromicin (CHEBI:37923) is a amino cyclitol glycoside (CHEBI:22479)
	astromicin (CHEBI:37923) is a aminoglycoside antibiotic (CHEBI:22507)
	astromicin (CHEBI:37923) is a diol (CHEBI:23824)
	astromicin (CHEBI:37923) is a monocarboxylic acid amide (CHEBI:29347)
	astromicin (CHEBI:37923) is a primary amino compound (CHEBI:50994)
Incoming Relation(s)
Incoming Relation(s)	astromycin sulfate (CHEBI:31242) has functional parent astromicin (CHEBI:37923)

IUPAC Name
N-[(1S,2R,3R,4S,5S,6R)-4-amino-3-({(2R,3R,6S)-3-amino-6-[(1S)-1-aminoethyl]tetrahydro-2H-pyran-2-yl}oxy)-2,5-dihydroxy-6-methoxycyclohexyl]-N-methylglycinamide

INNs	Source
astromicin	KEGG DRUG
astromicina	ChemIDplus
astromicine	ChemIDplus
astromicinum	ChemIDplus

Synonyms	Source
4-amino-1-(2-amino-N-methylacetamido)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranosyl)-6-O-methyl-L-chiro-inositol	ChEBI
4-amino-1-((aminoacetyl)methylamino)-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-β-L-lyxo-heptopyranosyl)-6-O-methyl-L-chiro-inositol	ChemIDplus
antibiotic KW-1070	ChemIDplus
ASTM	KEGG DRUG
Astromicin	KEGG COMPOUND
astromycin	ChEBI

Manual Xrefs	Databases
250	DrugCentral
Astromicin	Wikipedia
C17708	KEGG COMPOUND
D07470	KEGG DRUG

Registry Numbers	Sources
Reaxys:3570275	Reaxys
CAS:55779-06-1	KEGG COMPOUND
CAS:55779-06-1	ChemIDplus

Citations