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CHEBI:3766 - clozapine
| Formula | C18H19ClN4 |
| Net Charge | 0 |
| Average Mass | 326.831 |
| Monoisotopic Mass | 326.12982 |
| SMILES | CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1 |
| InChI | InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3 |
| InChIKey | QZUDBNBUXVUHMW-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Chemical Roles: | environmental contaminant Any minor or unwanted substance introduced into the environment that can have undesired effects. Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | histamine antagonist Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists. EC 3.4.21.26 (prolyl oligopeptidase) inhibitor Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of prolyl oligopeptidase (EC 3.4.21.26). muscarinic antagonist A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists. xenobiotic A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means. GABA antagonist A compound that inhibits the action of γ-aminobutyric acid. adrenergic antagonist An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. |
| Applications: | histamine antagonist Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists. serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists. muscarinic antagonist A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists. GABA antagonist A compound that inhibits the action of γ-aminobutyric acid. second generation antipsychotic Antipsychotic drugs which can have different modes of action but which tend to be less likely than first generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements. adrenergic antagonist An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. GABA modulator A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act. |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| clozapine (CHEBI:3766) has role adrenergic antagonist (CHEBI:37887) |
| clozapine (CHEBI:3766) has role dopaminergic antagonist (CHEBI:48561) |
| clozapine (CHEBI:3766) has role EC 3.4.21.26 (prolyl oligopeptidase) inhibitor (CHEBI:76779) |
| clozapine (CHEBI:3766) has role environmental contaminant (CHEBI:78298) |
| clozapine (CHEBI:3766) has role GABA antagonist (CHEBI:65259) |
| clozapine (CHEBI:3766) has role histamine antagonist (CHEBI:37956) |
| clozapine (CHEBI:3766) has role muscarinic antagonist (CHEBI:48876) |
| clozapine (CHEBI:3766) has role second generation antipsychotic (CHEBI:65191) |
| clozapine (CHEBI:3766) has role serotonergic antagonist (CHEBI:48279) |
| clozapine (CHEBI:3766) has role xenobiotic (CHEBI:35703) |
| clozapine (CHEBI:3766) is a N-arylpiperazine (CHEBI:46848) |
| clozapine (CHEBI:3766) is a N-methylpiperazine (CHEBI:46920) |
| clozapine (CHEBI:3766) is a benzodiazepine (CHEBI:22720) |
| clozapine (CHEBI:3766) is a organochlorine compound (CHEBI:36683) |
| IUPAC Name |
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| 8-chloro-11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine |
| INNs | Source |
|---|---|
| clozapine | ChEBI |
| clozapina | ChEBI |
| clozapinum | ChEBI |
| Synonyms | Source |
|---|---|
| Clozapine | KEGG COMPOUND |
| Clozapin | DrugBank |
| Citations |
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