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CHEBI:34892 - nocodazole

ChEBI IDCHEBI:34892
ChEBI Namenocodazole
Stars
DefinitionA member of the class of benzimidazoles that is benzimidalole which is substituted at position 2 by a (methoxycarbonyl)amino group and at position 5 by a 2-thienoyl group. It is an antineoplastic agent that exerts its effect by depolymerising microtubules.
Last Modified24 February 2016
DownloadsMolfile
FormulaC14H11N3O3S
Net Charge0
Average Mass301.327
Monoisotopic Mass301.05211
SMILESCOC(=O)Nc1nc2ccc(C(=O)c3cccs3)cc2n1
InChIInChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)
InChIKeyKYRVNWMVYQXFEU-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
antimitotic  Any compound that inhibits cell division (mitosis).
tubulin modulator  Any substance that interacts with tubulin to inhibit or promote polymerisation of microtubules.
microtubule-destabilising agent  Any substance that interacts with tubulin to inhibit polymerisation of microtubules.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
nocodazole (CHEBI:34892) has role antimitotic (CHEBI:64911)
nocodazole (CHEBI:34892) has role antineoplastic agent (CHEBI:35610)
nocodazole (CHEBI:34892) has role microtubule-destabilising agent (CHEBI:61951)
nocodazole (CHEBI:34892) has role tubulin modulator (CHEBI:60832)
nocodazole (CHEBI:34892) is a aromatic ketone (CHEBI:76224)
nocodazole (CHEBI:34892) is a benzimidazoles (CHEBI:22715)
nocodazole (CHEBI:34892) is a carbamate ester (CHEBI:23003)
nocodazole (CHEBI:34892) is a thiophenes (CHEBI:26961)
IUPAC Name 
methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate
INNs  Source
nocodazoleKEGG DRUG
nocodazolumChemIDplus
nocodazolChemIDplus
nocodazoleWHO MedNet
Synonyms  Source
methyl (5-(2-thienylcarbonyl))-1H-benzimidazole-2-ylcarbamateChemIDplus
N-(5-(2-thenoyl)-2-benzimidazolyl)carbamic acid methyl esterChemIDplus
(5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamic acid methyl esterChemIDplus
oncodazoleChemIDplus
N-(5-(2-thienoyl)-2-benzimidazolyl)carbamic acid methyl esterNIST Chemistry WebBook
methyl N-(5-thenoyl-2-benzimidazolyl)carbamateNIST Chemistry WebBook
Manual XrefsDatabases
C13719KEGG COMPOUND
D05197KEGG DRUG
DB08313DrugBank
NocodazoleWikipedia
NZOPDBeChem
LSM-2260LINCS
Registry NumbersSources
Reaxys:1085978Reaxys
CAS:31430-18-9KEGG COMPOUND
CAS:31430-18-9ChemIDplus
CAS:31430-18-9NIST Chemistry WebBook
Citations