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CHEBI:34892 - nocodazole

Default Structure
ChEBI IDCHEBI:34892
ChEBI Namenocodazole
Stars
DefinitionA member of the class of benzimidazoles that is benzimidalole which is substituted at position 2 by a (methoxycarbonyl)amino group and at position 5 by a 2-thienoyl group. It is an antineoplastic agent that exerts its effect by depolymerising microtubules.
Last Modified24 February 2016
DownloadsMolfile
FormulaC14H11N3O3S
Net Charge0
Average Mass301.327
Monoisotopic Mass301.05211
SMILESCOC(=O)Nc1nc2ccc(C(=O)c3cccs3)cc2n1
InChIInChI=1S/C14H11N3O3S/c1-20-14(19)17-13-15-9-5-4-8(7-10(9)16-13)12(18)11-3-2-6-21-11/h2-7H,1H3,(H2,15,16,17,19)
InChIKeyKYRVNWMVYQXFEU-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
microtubule-destabilising agent  Any substance that interacts with tubulin to inhibit polymerisation of microtubules.
antimitotic  Any compound that inhibits cell division (mitosis).
tubulin modulator  Any substance that interacts with tubulin to inhibit or promote polymerisation of microtubules.
Application:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
ChEBI Ontology
Outgoing Relation(s)
nocodazole (CHEBI:34892) has role antimitotic (CHEBI:64911)
nocodazole (CHEBI:34892) has role antineoplastic agent (CHEBI:35610)
nocodazole (CHEBI:34892) has role microtubule-destabilising agent (CHEBI:61951)
nocodazole (CHEBI:34892) has role tubulin modulator (CHEBI:60832)
nocodazole (CHEBI:34892) is a aromatic ketone (CHEBI:76224)
nocodazole (CHEBI:34892) is a benzimidazoles (CHEBI:22715)
nocodazole (CHEBI:34892) is a carbamate ester (CHEBI:23003)
nocodazole (CHEBI:34892) is a thiophenes (CHEBI:26961)
IUPAC Name 
methyl [5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]carbamate
INNs  Source
nocodazolChemIDplus
nocodazoleWHO MedNet
nocodazoleKEGG DRUG
nocodazolumChemIDplus
Synonyms  Source
(5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl)-carbamic acid methyl esterChemIDplus
N-(5-(2-thenoyl)-2-benzimidazolyl)carbamic acid methyl esterChemIDplus
N-(5-(2-thienoyl)-2-benzimidazolyl)carbamic acid methyl esterNIST Chemistry WebBook
methyl (5-(2-thienylcarbonyl))-1H-benzimidazole-2-ylcarbamateChemIDplus
methyl N-(5-thenoyl-2-benzimidazolyl)carbamateNIST Chemistry WebBook
NSC-238159ChEMBL
Manual XrefsDatabases
C13719KEGG COMPOUND
D05197KEGG DRUG
DB08313DrugBank
LSM-2260LINCS
NocodazoleWikipedia
NZOPDBeChem
Registry NumbersSources
Reaxys:1085978Reaxys
CAS:31430-18-9NIST Chemistry WebBook
CAS:31430-18-9KEGG COMPOUND
CAS:31430-18-9ChemIDplus
Citations