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CHEBI:34879 - NS 1619

ChEBI IDCHEBI:34879
ChEBI NameNS 1619
Stars
DefinitionA member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It is an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).
Last Modified25 February 2016
DownloadsMolfile
FormulaC15H8F6N2O2
Net Charge0
Average Mass362.229
Monoisotopic Mass362.04900
SMILESO=c1nc2cc(C(F)(F)F)ccc2n1-c1cc(C(F)(F)F)ccc1O
InChIInChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25)
InChIKeyYLFMCMWKHSDUCT-UHFFFAOYSA-N
Roles Classification
Biological Role:
potassium channel opener  A potassium channel modulator that opens the potassium channel.
ChEBI Ontology
Outgoing Relation(s)
NS 1619 (CHEBI:34879) has role potassium channel opener (CHEBI:79085)
NS 1619 (CHEBI:34879) is a (trifluoromethyl)benzenes (CHEBI:83565)
NS 1619 (CHEBI:34879) is a benzimidazoles (CHEBI:22715)
NS 1619 (CHEBI:34879) is a phenols (CHEBI:33853)
IUPAC Name 
1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-1,3-dihydro-2H-benzimidazol-2-one
Synonyms  Source
NS-1619ChemIDplus
1-(2'-hydroxy-5'-trifluoromethylphenyl)-5-trifluoromethyl-2(3H)-benzimidazoloneChemIDplus
NS1619ChEBI
5-trifluoromethyl-2,3-dihydro-1-(5-trifluoromethyl-2-hydroxyphenyl)-1H-2-oxo-benzimidazoleChEBI
1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-oneChEBI
Manual XrefsDatabases
C13833KEGG COMPOUND
LSM-3206LINCS
Registry NumbersSources
Reaxys:8165035Reaxys
CAS:153587-01-0KEGG COMPOUND
CAS:153587-01-0ChemIDplus
Citations