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CHEBI:3441 - carvedilol
| Formula | C24H26N2O4 |
| Net Charge | 0 |
| Average Mass | 406.482 |
| Monoisotopic Mass | 406.18926 |
| SMILES | COc1ccccc1OCCNCC(O)COc1cccc2nc3ccccc3c12 |
| InChI | InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3 |
| InChIKey | OGHNVEJMJSYVRP-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
|---|
| Chemical Role: | Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. beta-adrenergic antagonist An agent that binds to but does not activate β-adrenergic receptors thereby blocking the actions of endogenous or exogenous β-adrenergic agonists. β-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety. |
| Applications: | antiatherosclerotic agent A cardiovascular drug that prevents atherosclerosis (a disease in which the inside of an artery narrows due to the build up of plaque). Compare with antiatherogenic agent. alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. anticonvulsant A drug used to prevent seizures or reduce their severity. anti-arrhythmia drug A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. beta-adrenergic antagonist An agent that binds to but does not activate β-adrenergic receptors thereby blocking the actions of endogenous or exogenous β-adrenergic agonists. β-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety. hypoglycemic agent A drug which lowers the blood glucose level. renoprotective agent Any compound that is able to prevent damage to the kidneys. antirheumatic drug A drug used to treat rheumatoid arthritis. vasodilator agent A drug used to cause dilation of the blood vessels. hyperglycemic agent A drug which increases the blood glucose level. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| carvedilol (CHEBI:3441) has role anti-arrhythmia drug (CHEBI:38070) |
| carvedilol (CHEBI:3441) has role antiatherosclerotic agent (CHEBI:145947) |
| carvedilol (CHEBI:3441) has role anticonvulsant (CHEBI:35623) |
| carvedilol (CHEBI:3441) has role antidepressant (CHEBI:35469) |
| carvedilol (CHEBI:3441) has role antihypertensive agent (CHEBI:35674) |
| carvedilol (CHEBI:3441) has role antineoplastic agent (CHEBI:35610) |
| carvedilol (CHEBI:3441) has role antirheumatic drug (CHEBI:35842) |
| carvedilol (CHEBI:3441) has role cardiovascular drug (CHEBI:35554) |
| carvedilol (CHEBI:3441) has role hyperglycemic agent (CHEBI:76916) |
| carvedilol (CHEBI:3441) has role hypoglycemic agent (CHEBI:35526) |
| carvedilol (CHEBI:3441) has role renoprotective agent (CHEBI:231911) |
| carvedilol (CHEBI:3441) has role vasodilator agent (CHEBI:35620) |
| carvedilol (CHEBI:3441) has role α-adrenergic antagonist (CHEBI:37890) |
| carvedilol (CHEBI:3441) has role β-adrenergic antagonist (CHEBI:35530) |
| carvedilol (CHEBI:3441) is a carbazoles (CHEBI:48513) |
| carvedilol (CHEBI:3441) is a secondary alcohol (CHEBI:35681) |
| carvedilol (CHEBI:3441) is a secondary amino compound (CHEBI:50995) |
| IUPAC Name |
|---|
| 1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol |
| INNs | Source |
|---|---|
| carvedilol | WHO MedNet |
| carvedilol | ChemIDplus |
| carvédilol | WHO MedNet |
| carvedilolum | WHO MedNet |
| Synonyms | Source |
|---|---|
| (+-)-1-(Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol | ChemIDplus |
| BM 14.190 | ChEMBL |
| BM-14-190 | ChEMBL |
| BM-14.190 | ChEMBL |
| BM-14190 | ChEMBL |
| C07AG02 | ChEMBL |
| Brand Names | Source |
|---|---|
| Artist | ChEMBL |
| Coreg | ChEMBL |
| Eucardic 12.5 | ChEMBL |
| Eucardic 25 | ChEMBL |
| Eucardic 3.125 | ChEMBL |
| Eucardic 6.25 | ChEMBL |
| Manual Xrefs | Databases |
|---|---|
| 522 | DrugCentral |
| C06875 | KEGG COMPOUND |
| Carvedilol | Wikipedia |
| D00255 | KEGG DRUG |
| DB01136 | DrugBank |
| DE2815926 | Patent |
| HMDB0015267 | HMDB |
| LSM-1310 | LINCS |
| US4503067 | Patent |
| Registry Numbers | Sources |
|---|---|
| Reaxys:1514452 | Reaxys |
| CAS:72956-09-3 | KEGG COMPOUND |
| CAS:72956-09-3 | ChemIDplus |
| Citations |
|---|