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CHEBI:3441 - carvedilol
| Formula | C24H26N2O4 |
| Net Charge | 0 |
| Average Mass | 406.482 |
| Monoisotopic Mass | 406.18926 |
| SMILES | COc1ccccc1OCCNCC(O)COc1cccc2nc3ccccc3c12 |
| InChI | InChI=1S/C24H26N2O4/c1-28-21-10-4-5-11-22(21)29-14-13-25-15-17(27)16-30-23-12-6-9-20-24(23)18-7-2-3-8-19(18)26-20/h2-12,17,25-27H,13-16H2,1H3 |
| InChIKey | OGHNVEJMJSYVRP-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
|---|
| Chemical Role: | Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Biological Roles: | beta-adrenergic antagonist An agent that binds to but does not activate β-adrenergic receptors thereby blocking the actions of endogenous or exogenous β-adrenergic agonists. β-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety. alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. |
| Applications: | hypoglycemic agent A drug which lowers the blood glucose level. beta-adrenergic antagonist An agent that binds to but does not activate β-adrenergic receptors thereby blocking the actions of endogenous or exogenous β-adrenergic agonists. β-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. renoprotective agent Any compound that is able to prevent damage to the kidneys. hyperglycemic agent A drug which increases the blood glucose level. anticonvulsant A drug used to prevent seizures or reduce their severity. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. antiatherosclerotic agent A cardiovascular drug that prevents atherosclerosis (a disease in which the inside of an artery narrows due to the build up of plaque). Compare with antiatherogenic agent. vasodilator agent A drug used to cause dilation of the blood vessels. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. alpha-adrenergic antagonist An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. antirheumatic drug A drug used to treat rheumatoid arthritis. anti-arrhythmia drug A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| carvedilol (CHEBI:3441) has role anti-arrhythmia drug (CHEBI:38070) |
| carvedilol (CHEBI:3441) has role antiatherosclerotic agent (CHEBI:145947) |
| carvedilol (CHEBI:3441) has role anticonvulsant (CHEBI:35623) |
| carvedilol (CHEBI:3441) has role antidepressant (CHEBI:35469) |
| carvedilol (CHEBI:3441) has role antihypertensive agent (CHEBI:35674) |
| carvedilol (CHEBI:3441) has role antineoplastic agent (CHEBI:35610) |
| carvedilol (CHEBI:3441) has role antirheumatic drug (CHEBI:35842) |
| carvedilol (CHEBI:3441) has role cardiovascular drug (CHEBI:35554) |
| carvedilol (CHEBI:3441) has role hyperglycemic agent (CHEBI:76916) |
| carvedilol (CHEBI:3441) has role hypoglycemic agent (CHEBI:35526) |
| carvedilol (CHEBI:3441) has role renoprotective agent (CHEBI:231911) |
| carvedilol (CHEBI:3441) has role vasodilator agent (CHEBI:35620) |
| carvedilol (CHEBI:3441) has role α-adrenergic antagonist (CHEBI:37890) |
| carvedilol (CHEBI:3441) has role β-adrenergic antagonist (CHEBI:35530) |
| carvedilol (CHEBI:3441) is a carbazoles (CHEBI:48513) |
| carvedilol (CHEBI:3441) is a secondary alcohol (CHEBI:35681) |
| carvedilol (CHEBI:3441) is a secondary amino compound (CHEBI:50995) |
| IUPAC Name |
|---|
| 1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol |
| INNs | Source |
|---|---|
| carvedilol | WHO MedNet |
| carvedilol | ChemIDplus |
| carvédilol | WHO MedNet |
| carvedilolum | WHO MedNet |
| Synonyms | Source |
|---|---|
| (+-)-1-(Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol | ChemIDplus |
| BM 14.190 | ChEMBL |
| BM-14-190 | ChEMBL |
| BM-14.190 | ChEMBL |
| BM-14190 | ChEMBL |
| C07AG02 | ChEMBL |
| Brand Names | Source |
|---|---|
| Artist | ChEMBL |
| Coreg | ChEMBL |
| Eucardic 12.5 | ChEMBL |
| Eucardic 25 | ChEMBL |
| Eucardic 3.125 | ChEMBL |
| Eucardic 6.25 | ChEMBL |
| Manual Xrefs | Databases |
|---|---|
| 522 | DrugCentral |
| C06875 | KEGG COMPOUND |
| Carvedilol | Wikipedia |
| D00255 | KEGG DRUG |
| DB01136 | DrugBank |
| DE2815926 | Patent |
| HMDB0015267 | HMDB |
| LSM-1310 | LINCS |
| US4503067 | Patent |
| Registry Numbers | Sources |
|---|---|
| Reaxys:1514452 | Reaxys |
| CAS:72956-09-3 | KEGG COMPOUND |
| CAS:72956-09-3 | ChemIDplus |
| Citations |
|---|