EMBL-EBI | Chemical Biology | ChEBI
Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search
CHEBI:32293 - verteporfin
| ChEBI ID | CHEBI:32293 |
| ChEBI Name | verteporfin |
| Stars | |
| Definition | An equimolar mixture of the 9-methyl ester and 13-methyl ester of trans-(±)-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropanoic acid. It is used as a photosensitizer in photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with neovascular (wet) age-related macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when activated by red (693 nm) laser light in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels. |
| Last Modified | 15 October 2015 |
| Roles Classification |
|---|
| Biological Role: | autophagy inhibitor Any compound that inhibits the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell). |
| Applications: | photosensitizing agent A chemical compound that can be excited by light of a specific wavelength and subsequently transfer energy to a chosen reactant. This is commonly molecular oxygen within a cancer tissue, which is converted to (highly rective) singlet state oxygen. This rapidly reacts with any nearby biomolecules, ultimately killing the cancer cells. ophthalmology drug Any compound used for the treatment of eye conditions or eye diseases. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| verteporfin (CHEBI:32293) has part (2R,21S)-8-ethenyl-21,22-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,21-dihydrobenzo[b]porphyrin-13-propanoic acid (CHEBI:60775) |
| verteporfin (CHEBI:32293) has part (2R,21S)8-ethenyl-21,22-bis(methoxycarbonyl)-13-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,21-dihydrobenzo[b]porphyrin-17-propanoic acid (CHEBI:60778) |
| verteporfin (CHEBI:32293) has part (2S,21R)-8-ethenyl-21,22-bis(methoxycarbonyl)-13-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,21-dihydrobenzo[b]porphyrin-17-propanoic acid (CHEBI:60779) |
| verteporfin (CHEBI:32293) has part (2S,21R)-8-ethenyl-21,22-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,21-dihydrobenzo[b]porphyrin-13-propanoic acid (CHEBI:60776) |
| verteporfin (CHEBI:32293) has role antineoplastic agent (CHEBI:35610) |
| verteporfin (CHEBI:32293) has role autophagy inhibitor (CHEBI:88230) |
| verteporfin (CHEBI:32293) has role ophthalmology drug (CHEBI:66981) |
| verteporfin (CHEBI:32293) has role photosensitizing agent (CHEBI:47868) |
| verteporfin (CHEBI:32293) is a mixture (CHEBI:60004) |
| verteporfin (CHEBI:32293) is a organic molecular entity (CHEBI:50860) |
| INNs | Source |
|---|---|
| verteporfin | ChemIDplus |
| verteporfina | WHO MedNet |
| verteporfine | WHO MedNet |
| Synonyms | Source |
|---|---|
| Bpd-ma | ChEMBL |
| CL 318,952 | ChEMBL |
| CL-318952 | ChEMBL |
| trans-(±)-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester | ChEBI |
| trans-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester | ChEBI |
| trans-(±)-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropionic acid monomethyl ester | ChEBI |
| Brand Name | Source |
|---|---|
| Visudyne | ChemIDplus |
| Registry Numbers | Sources |
|---|---|
| Reaxys:13501128 | Reaxys |
| Reaxys:13501141 | Reaxys |
| CAS:129497-78-5 | KEGG DRUG |
| CAS:129497-78-5 | ChemIDplus |
| Citations |
|---|