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CHEBI:32293 - verteporfin
| ChEBI ID | CHEBI:32293 |
| ChEBI Name | verteporfin |
| Stars | |
| Definition | An equimolar mixture of the 9-methyl ester and 13-methyl ester of trans-(±)-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropanoic acid. It is used as a photosensitizer in photodynamic therapy to eliminate the abnormal blood vessels in the eye associated with neovascular (wet) age-related macular degeneration. Verteporfin accumulates in these abnormal blood vessels and, when activated by red (693 nm) laser light in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to the endothelium and blockage of the vessels. |
| Last Modified | 15 October 2015 |
| Roles Classification |
|---|
| Biological Role: | autophagy inhibitor Any compound that inhibits the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell). |
| Applications: | antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. photosensitizing agent A chemical compound that can be excited by light of a specific wavelength and subsequently transfer energy to a chosen reactant. This is commonly molecular oxygen within a cancer tissue, which is converted to (highly rective) singlet state oxygen. This rapidly reacts with any nearby biomolecules, ultimately killing the cancer cells. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| verteporfin (CHEBI:32293) has part (2R,21S)-8-ethenyl-21,22-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,21-dihydrobenzo[b]porphyrin-13-propanoic acid (CHEBI:60775) |
| verteporfin (CHEBI:32293) has part (2R,21S)8-ethenyl-21,22-bis(methoxycarbonyl)-13-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,21-dihydrobenzo[b]porphyrin-17-propanoic acid (CHEBI:60778) |
| verteporfin (CHEBI:32293) has part (2S,21R)-8-ethenyl-21,22-bis(methoxycarbonyl)-13-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,21-dihydrobenzo[b]porphyrin-17-propanoic acid (CHEBI:60779) |
| verteporfin (CHEBI:32293) has part (2S,21R)-8-ethenyl-21,22-bis(methoxycarbonyl)-17-(3-methoxy-3-oxopropyl)-2,7,12,18-tetramethyl-2,21-dihydrobenzo[b]porphyrin-13-propanoic acid (CHEBI:60776) |
| verteporfin (CHEBI:32293) has role antineoplastic agent (CHEBI:35610) |
| verteporfin (CHEBI:32293) has role autophagy inhibitor (CHEBI:88230) |
| verteporfin (CHEBI:32293) has role photosensitizing agent (CHEBI:47868) |
| verteporfin (CHEBI:32293) is a mixture (CHEBI:60004) |
| INN | Source |
|---|---|
| verteporfin | ChemIDplus |
| Synonyms | Source |
|---|---|
| trans-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester | ChEBI |
| trans-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropionic acid monomethyl ester | ChEBI |
| trans-(±)-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropanoic acid monomethyl ester | ChEBI |
| trans-(±)-18-ethenyl-4,4a-dihydro-3,4-bis(methoxycarbonyl)-4a,8,14,19-tetramethyl-23H,25H-benzo[b]porphine-9,13-dipropionic acid monomethyl ester | ChEBI |
| Brand Name | Source |
|---|---|
| Visudyne | ChemIDplus |
| Registry Numbers | Sources |
|---|---|
| Reaxys:13501128 | Reaxys |
| Reaxys:13501141 | Reaxys |
| CAS:129497-78-5 | KEGG DRUG |
| CAS:129497-78-5 | ChemIDplus |
| Citations |
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