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CHEBI:32192 - tenoxicam

ChEBI IDCHEBI:32192
ChEBI Nametenoxicam
Stars
DefinitionA thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine. Used for the treatment of pain and inflammation in osteoarthritis and rheumatoid arthritis. It is also indicated for short term treatment of acute musculoskeletal disorders including strains, sprains and other soft-tissue injuries.
Last Modified19 June 2017
DownloadsMolfile
FormulaC13H11N3O4S2
Net Charge0
Average Mass337.382
Monoisotopic Mass337.01910
SMILESCN1C(C(=O)Nc2ccccn2)=C(O)c2sccc2S1(=O)=O
InChIInChI=1S/C13H11N3O4S2/c1-16-10(13(18)15-9-4-2-3-6-14-9)11(17)12-8(5-7-21-12)22(16,19)20/h2-7,17H,1H3,(H,14,15,18)
InChIKeyLZNWYQJJBLGYLT-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
non-narcotic analgesic  A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor  A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.
Applications:
antipyretic  A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.
non-narcotic analgesic  A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
non-steroidal anti-inflammatory drug  An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
ChEBI Ontology
Outgoing Relation(s)
tenoxicam (CHEBI:32192) has role antipyretic (CHEBI:35493)
tenoxicam (CHEBI:32192) has role EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (CHEBI:35544)
tenoxicam (CHEBI:32192) has role non-narcotic analgesic (CHEBI:35481)
tenoxicam (CHEBI:32192) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
tenoxicam (CHEBI:32192) is a heteroaryl hydroxy compound (CHEBI:74818)
tenoxicam (CHEBI:32192) is a monocarboxylic acid amide (CHEBI:29347)
tenoxicam (CHEBI:32192) is a pyridines (CHEBI:26421)
tenoxicam (CHEBI:32192) is a thienothiazine (CHEBI:46977)
IUPAC Name 
4-hydroxy-2-methyl-N-(pyridin-2-yl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide
INNs  Source
tenoxicamKEGG DRUG
tenoxicamumDrugBank
tenoxicamWHO MedNet
ténoxicamWHO MedNet
Brand Names  Source
MobiflexChEBI
TilcotilKEGG DRUG
Manual XrefsDatabases
D01767KEGG DRUG
DB00469DrugBank
US2008014272Patent
US4687766Patent
TenoxicamWikipedia
2595DrugCentral
Registry NumbersSources
Reaxys:572193Reaxys
CAS:59804-37-4KEGG DRUG
CAS:59804-37-4ChemIDplus
Citations