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CHEBI:32016 - pirfenidone
| Formula | C12H11NO |
| Net Charge | 0 |
| Average Mass | 185.226 |
| Monoisotopic Mass | 185.08406 |
| SMILES | Cc1ccc(=O)n(-c2ccccc2)c1 |
| InChI | InChI=1S/C12H11NO/c1-10-7-8-12(14)13(9-10)11-5-3-2-4-6-11/h2-9H,1H3 |
| InChIKey | ISWRGOKTTBVCFA-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
|---|
| Biological Roles: | non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. antiviral agent A substance that destroys or inhibits replication of viruses. |
| Applications: | non-narcotic analgesic A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. non-steroidal anti-inflammatory drug An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. cardiovascular drug A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume. nephroprotective agent Any protective agent that is able to prevent damage to the kidney. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. antipyretic A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever. antifibrotic agent Any agent which acts to reduce fibrosis. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| pirfenidone (CHEBI:32016) has role antifibrotic agent (CHEBI:233423) |
| pirfenidone (CHEBI:32016) has role antimicrobial agent (CHEBI:33281) |
| pirfenidone (CHEBI:32016) has role antineoplastic agent (CHEBI:35610) |
| pirfenidone (CHEBI:32016) has role antipyretic (CHEBI:35493) |
| pirfenidone (CHEBI:32016) has role antiviral agent (CHEBI:22587) |
| pirfenidone (CHEBI:32016) has role cardiovascular drug (CHEBI:35554) |
| pirfenidone (CHEBI:32016) has role immunosuppressive agent (CHEBI:35705) |
| pirfenidone (CHEBI:32016) has role nephroprotective agent (CHEBI:76595) |
| pirfenidone (CHEBI:32016) has role non-narcotic analgesic (CHEBI:35481) |
| pirfenidone (CHEBI:32016) has role non-steroidal anti-inflammatory drug (CHEBI:35475) |
| pirfenidone (CHEBI:32016) is a pyridone (CHEBI:38183) |
| IUPAC Name |
|---|
| 5-methyl-1-phenylpyridin-2(1H)-one |
| INNs | Source |
|---|---|
| pirfenidona | ChemIDplus |
| pirfenidone | ChemIDplus |
| pirfenidone | KEGG DRUG |
| pirfenidonum | ChemIDplus |
| Synonyms | Source |
|---|---|
| AMR 69 | ChemIDplus |
| AMR-69 | ChemIDplus |
| NSC-748456 | ChEMBL |
| Pirespa | ChEMBL |
| Pirfenidone | KEGG COMPOUND |
| Brand Names | Source |
|---|---|
| Esbriet | KEGG DRUG |
| Pirfenidone axunio (previously pirfenidone aet) | ChEMBL |
| Pirfenidone component of esbriet | ChEMBL |
| Pirfenidone viatris | ChEMBL |
| Manual Xrefs | Databases |
|---|---|
| 4224 | DrugCentral |
| D01583 | KEGG DRUG |
| LSM-4190 | LINCS |
| Pirfenidone | Wikipedia |
| Registry Numbers | Sources |
|---|---|
| Reaxys:1526549 | Reaxys |
| CAS:53179-13-8 | KEGG DRUG |
| CAS:53179-13-8 | ChemIDplus |
| Citations |
|---|