periciazine (CHEBI:31981)

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CHEBI:31981 - periciazine

ChEBI ID	CHEBI:31981
ChEBI Name	periciazine
Stars
Definition	A member of the class of phenothiazines that is 10H-phenothiazine substituted by a 3-(4-hydroxypiperidin-1-yl)propyl group at the nitrogen atom and a carbonitrile group at position 2. Periciazine is a first generation antipsychotic.
Last Modified	22 February 2017
Downloads	Molfile

Formula	C21H23N3OS
Net Charge	0
Average Mass	365.502
Monoisotopic Mass	365.15618
SMILES	N#Cc1ccc2c(c1)N(CCCN1CCC(O)CC1)c1ccccc1S2
InChI	InChI=1S/C21H23N3OS/c22-15-16-6-7-21-19(14-16)24(18-4-1-2-5-20(18)26-21)11-3-10-23-12-8-17(25)9-13-23/h1-2,4-7,14,17,25H,3,8-13H2
InChIKey	LUALIOATIOESLM-UHFFFAOYSA-N

Wikipedia

Roles Classification

Biological Role:

adrenergic antagonist An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists.

Applications:

first generation antipsychotic Antipsychotic drugs which can have different modes of action but which tend to be more likely than second generation antipsychotics to cause extrapyramidal motor control disabilities such as body rigidity or Parkinson's disease-type movements; such body movements can become permanent even after treatment has ceased.

adrenergic antagonist An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists.

sedative A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.

ChEBI Ontology

Outgoing Relation(s)
	periciazine (CHEBI:31981) has parent hydride 10H-phenothiazine (CHEBI:37931)
	periciazine (CHEBI:31981) has role adrenergic antagonist (CHEBI:37887)
	periciazine (CHEBI:31981) has role first generation antipsychotic (CHEBI:65190)
	periciazine (CHEBI:31981) has role sedative (CHEBI:35717)
	periciazine (CHEBI:31981) is a hydroxypiperidine (CHEBI:48590)
	periciazine (CHEBI:31981) is a nitrile (CHEBI:18379)
	periciazine (CHEBI:31981) is a phenothiazines (CHEBI:38093)

IUPAC Name
10-[3-(4-hydroxypiperidin-1-yl)propyl]-10H-phenothiazine-2-carbonitrile

INNs	Source
periciazine	WHO MedNet
periciazinum	WHO MedNet
périciazine	WHO MedNet
periciazina	WHO MedNet

Synonyms	Source
10-(3-(4-Hydroxypiperidino)propyl)phenothiazine-2-carbonitrile	ChemIDplus
2-Cyano-10-(3-(4-hydroxy-1-piperidyl)propyl)phenothiazine	ChemIDplus
2-Cyano-10-(3-(4-hydroxypiperidino)propyl)phenothiazine	ChemIDplus
Cyano-3 ((hydroxy-4 piperidyl-1)-3 propyl)-10 phenothiazine	ChemIDplus
Piperocyanomazine	ChemIDplus
Propericiazine	ChemIDplus

Manual Xrefs	Databases
D01485	KEGG DRUG
FR1212031	Patent
DB01608	DrugBank
HMDB0015546	HMDB
Periciazine	Wikipedia
LSM-24971	LINCS
2107	DrugCentral

Registry Numbers	Sources
Reaxys:576739	Reaxys
CAS:2622-26-6	ChemIDplus

Citations