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CHEBI:3176 - brinzolamide
| Formula | C12H21N3O5S3 |
| Net Charge | 0 |
| Average Mass | 383.517 |
| Monoisotopic Mass | 383.06433 |
| SMILES | CCN[C@H]1CN(CCCOC)S(=O)(=O)c2sc(S(N)(=O)=O)cc21 |
| InChI | InChI=1S/C12H21N3O5S3/c1-3-14-10-8-15(5-4-6-20-2)23(18,19)12-9(10)7-11(21-12)22(13,16)17/h7,10,14H,3-6,8H2,1-2H3,(H2,13,16,17)/t10-/m0/s1 |
| InChIKey | HCRKCZRJWPKOAR-JTQLQIEISA-N |
| Wikipedia |
|---|
| Roles Classification |
|---|
| Biological Role: | EC 4.2.1.1 (carbonic anhydrase) inhibitor An EC 4.2.1.* (hydro-lyases) inhibitor that interferes with the action of carbonic anhydrase (EC 4.2.1.1). Such compounds reduce the secretion of H+ ions by the proximal kidney tubule. |
| Application: | antiglaucoma drug Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| brinzolamide (CHEBI:3176) has role antiglaucoma drug (CHEBI:39456) |
| brinzolamide (CHEBI:3176) has role EC 4.2.1.1 (carbonic anhydrase) inhibitor (CHEBI:23018) |
| brinzolamide (CHEBI:3176) is a sulfonamide (CHEBI:35358) |
| brinzolamide (CHEBI:3176) is a thienothiazine (CHEBI:46977) |
| Incoming Relation(s) |
| 3,4-didehydro-N4-deethylbrinzolamide (CHEBI:43411) has functional parent brinzolamide (CHEBI:3176) |
| IUPAC Name |
|---|
| (4R)-4-(ethylamino)-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide |
| Synonyms | Source |
|---|---|
| Azopt | KEGG DRUG |
| Brinzolamide | KEGG COMPOUND |
| Registry Numbers | Sources |
|---|---|
| Beilstein:9651552 | Beilstein |
| CAS:138890-62-7 | ChemIDplus |
| CAS:138890-62-7 | KEGG COMPOUND |