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CHEBI:31687 - idebenone

Default Structure
ChEBI IDCHEBI:31687
ChEBI Nameidebenone
Stars
DefinitionA member of the class of 1,4-benzoquinones which is substituted by methoxy groups at positions 2 and 3, by a methyl group at positions 5, and by a 10-hydroxydecyl group at positions 6. Initially developed for the treatment of Alzheimer's disease, benefits were modest; it was subsequently found to be of benefit for the symptomatic treatment of Friedreich's ataxia.
Last Modified26 May 2021
DownloadsMolfile
FormulaC19H30O5
Net Charge0
Average Mass338.444
Monoisotopic Mass338.20932
SMILESCOC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O
InChIInChI=1S/C19H30O5/c1-14-15(12-10-8-6-4-5-7-9-11-13-20)17(22)19(24-3)18(23-2)16(14)21/h20H,4-13H2,1-3H3
InChIKeyJGPMMRGNQUBGND-UHFFFAOYSA-N
Wikipedia
Roles Classification
Chemical Role:
antioxidant  A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
Biological Roles:
immunosuppressive agent  An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
ferroptosis inhibitor  Any substance that inhibits the process of ferroptosis (a type of programmed cell death dependent on iron and characterized by the accumulation of lipid peroxides) in organisms.
Application:
immunosuppressive agent  An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response.
ChEBI Ontology
Outgoing Relation(s)
idebenone (CHEBI:31687) has role antioxidant (CHEBI:22586)
idebenone (CHEBI:31687) has role ferroptosis inhibitor (CHEBI:173084)
idebenone (CHEBI:31687) has role immunosuppressive agent (CHEBI:35705)
idebenone (CHEBI:31687) is a 1,4-benzoquinones (CHEBI:132124)
idebenone (CHEBI:31687) is a primary alcohol (CHEBI:15734)
IUPAC Name 
2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-1,4-benzoquinone
INNs  Source
idebenonaWHO MedNet
idebenoneWHO MedNet
idébénoneWHO MedNet
idebenonumWHO MedNet
Synonyms  Source
2-(10-hydroxydecyl)-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dioneIUPAC
2-(10-hydroxydecyl)-5,6-dimethoxy-3-methyl-p-benzoquinoneChemIDplus
2,3-dimethoxy-5-methyl-6-(10'-hydroxydecyl)-1,4-benzoquinoneChEBI
6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinoneChemIDplus
6-(10-hydroxydecyl)-2,3-dimethoxy-5-methyl-p-benzoquinoneChEBI
CV 2619ChemIDplus
Brand Name  Source
RaxoneDrugBank
Manual XrefsDatabases
1416DrugCentral
3558ChemSpider
D01750KEGG DRUG
DB09081DrugBank
DE2519730Patent
IdebenoneWikipedia
LSM-5505LINCS
US4271083Patent
Registry NumbersSources
Reaxys:2001459Reaxys
CAS:58186-27-9ChemIDplus
Citations