fluocinolone acetonide (CHEBI:31623)

Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search

CHEBI:31623 - fluocinolone acetonide

ChEBI ID	CHEBI:31623
ChEBI Name	fluocinolone acetonide
Stars
Definition	A fluorinated steroid that is flunisolide in which the hydrogen at position 9 is replaced by fluorine. A corticosteroid with glucocorticoid activity, it is used (both as the anhydrous form and as the dihydrate) in creams, gels and ointments for the treatment of various skin disorders.
Last Modified	6 February 2018
Downloads	Molfile

Formula	C24H30F2O6
Net Charge	0
Average Mass	452.494
Monoisotopic Mass	452.20105
SMILES	[H][C@@]12C[C@@]3([H])OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(F)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@@]21C
InChI	InChI=1S/C24H30F2O6/c1-20(2)31-19-9-13-14-8-16(25)15-7-12(28)5-6-21(15,3)23(14,26)17(29)10-22(13,4)24(19,32-20)18(30)11-27/h5-7,13-14,16-17,19,27,29H,8-11H2,1-4H3/t13-,14-,16-,17-,19+,21-,22-,23-,24+/m0/s1
InChIKey	FEBLZLNTKCEFIT-VSXGLTOVSA-N

Wikipedia

Roles Classification

Biological Role:

hormone Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.

Applications:

antiinfective agent A substance used in the prophylaxis or therapy of infectious diseases.

antipruritic drug A drug, usually applied topically, that relieves pruritus (itching).

anti-inflammatory drug A substance that reduces or suppresses inflammation.

dermatologic drug A drug used to treat or prevent skin disorders or for the routine care of skin.

antiglaucoma drug Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye.

antipsoriatic A drug used to treat psoriasis.

ophthalmology drug Any compound used for the treatment of eye conditions or eye diseases.

anti-inflammatory agent Any compound that has anti-inflammatory effects.

ChEBI Ontology

Outgoing Relation(s)
	fluocinolone acetonide (CHEBI:31623) has role anti-inflammatory agent (CHEBI:67079)
	fluocinolone acetonide (CHEBI:31623) has role anti-inflammatory drug (CHEBI:35472)
	fluocinolone acetonide (CHEBI:31623) has role antiglaucoma drug (CHEBI:39456)
	fluocinolone acetonide (CHEBI:31623) has role antiinfective agent (CHEBI:35441)
	fluocinolone acetonide (CHEBI:31623) has role antipruritic drug (CHEBI:59683)
	fluocinolone acetonide (CHEBI:31623) has role antipsoriatic (CHEBI:50748)
	fluocinolone acetonide (CHEBI:31623) has role dermatologic drug (CHEBI:50177)
	fluocinolone acetonide (CHEBI:31623) has role ophthalmology drug (CHEBI:66981)
	fluocinolone acetonide (CHEBI:31623) is a 11β-hydroxy steroid (CHEBI:35346)
	fluocinolone acetonide (CHEBI:31623) is a 20-oxo steroid (CHEBI:36885)
	fluocinolone acetonide (CHEBI:31623) is a 21-hydroxy steroid (CHEBI:35344)
	fluocinolone acetonide (CHEBI:31623) is a 3-oxo-Δ¹,Δ⁴-steroid (CHEBI:77166)
	fluocinolone acetonide (CHEBI:31623) is a cyclic ketal (CHEBI:59779)
	fluocinolone acetonide (CHEBI:31623) is a fluorinated steroid (CHEBI:50830)
	fluocinolone acetonide (CHEBI:31623) is a glucocorticoid (CHEBI:24261)
	fluocinolone acetonide (CHEBI:31623) is a organic heteropentacyclic compound (CHEBI:38164)
	fluocinolone acetonide (CHEBI:31623) is a primary α-hydroxy ketone (CHEBI:139590)

IUPAC Name
(4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS,12S)-4b,12-difluoro-6b-glycoloyl-5-hydroxy-4a,6a,8,8-tetramethyl-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one

INNs	Source
acétonide de fluocinolone	WHO MedNet
acetónido de fluocinolona	WHO MedNet
fluocinolone acetonide	WHO MedNet
fluocinoloni acetonidum	WHO MedNet

Synonyms	Source
6α,9α-difluoro-16α-hydroxyprednisolone 16,17-acetonide	ChemIDplus
6α-fluorotriamcinolone acetonide	ChemIDplus
Flucinolone acetonide	ChEMBL
Fluocinolide (acetate)	ChEMBL
fluocinolone 16,17-acetonide	ChemIDplus
NSC-92339	ChEMBL

Brand Names	Source
Capex	ChEMBL
Coriphate	ChemIDplus
Cortiplastol	ChemIDplus
Dermalar	ChemIDplus
Derma-Smoothe/FS	ChemIDplus
Dermotic	ChEMBL

Manual Xrefs	Databases
1204	DrugCentral
D01825	KEGG DRUG
DB00591	DrugBank
Fluocinolone_acetonide	Wikipedia
HMDB0014729	HMDB
US3014938	Patent
US3126375	Patent

Registry Numbers	Sources
Reaxys:1358396	Reaxys
CAS:67-73-2	ChemIDplus

Citations