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CHEBI:31593 - fasudil hydrochloride
| Formula | C14H17N3O2S.HCl |
| Net Charge | 0 |
| Average Mass | 327.837 |
| Monoisotopic Mass | 327.08083 |
| SMILES | Cl.O=S(=O)(c1cccc2cnccc12)N1CCCNCC1 |
| InChI | InChI=1S/C14H17N3O2S.ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;/h1,3-5,7,11,15H,2,6,8-10H2;1H |
| InChIKey | LFVPBERIVUNMGV-UHFFFAOYSA-N |
| Roles Classification |
|---|
| Biological Roles: | calcium channel blocker One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools. EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine. |
| Applications: | neuroprotective agent Any compound that can be used for the treatment of neurodegenerative disorders. nootropic agent Any compound that improves mental functions such as cognition, memory, intelligence, motivation, attention, and concentration. vasodilator agent A drug used to cause dilation of the blood vessels. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| fasudil hydrochloride (CHEBI:31593) has part fasudil(1+) (CHEBI:180694) |
| fasudil hydrochloride (CHEBI:31593) has role antihypertensive agent (CHEBI:35674) |
| fasudil hydrochloride (CHEBI:31593) has role calcium channel blocker (CHEBI:38215) |
| fasudil hydrochloride (CHEBI:31593) has role EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor (CHEBI:50925) |
| fasudil hydrochloride (CHEBI:31593) has role neuroprotective agent (CHEBI:63726) |
| fasudil hydrochloride (CHEBI:31593) has role nootropic agent (CHEBI:66980) |
| fasudil hydrochloride (CHEBI:31593) has role vasodilator agent (CHEBI:35620) |
| fasudil hydrochloride (CHEBI:31593) is a hydrochloride (CHEBI:36807) |
| Incoming Relation(s) |
| fasudil hydrochloride hydrate (CHEBI:180695) has part fasudil hydrochloride (CHEBI:31593) |
| IUPAC Name |
|---|
| 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline hydrochloride |
| Synonyms | Source |
|---|---|
| fasudil HCl | DrugBank |
| 1-(5-isoquinolinesulfonyl)homopiperazine hydrochloride | ChEBI |
| AT 877 hydrochloride | ChemIDplus |
| 4-(isoquinolin-5-ylsulfonyl)-1,4-diazepan-1-ium chloride | IUPAC |
| hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine monohydrochloride | ChemIDplus |
| HA 1077 hydrochloride | ChemIDplus |
| Manual Xrefs | Databases |
|---|---|
| DBSALT002399 | DrugBank |
| D01840 | KEGG DRUG |
| CN101863880 | Patent |
| Registry Numbers | Sources |
|---|---|
| CAS:105628-07-7 | ChemIDplus |
| Citations |
|---|