fabesetron (CHEBI:31588)

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CHEBI:31588 - fabesetron

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ChEBI ID	CHEBI:31588
ChEBI Name	fabesetron
Stars
Definition	An organic heterotricyclic compound that is 8,9-dihydropyrido[1,2-a]indol-6(7H)-one substituted by a (5-methyl-1H-imidazol-4-yl)methyl group at position 7R and a methyl group at position 10. It is a dual 5-HT3 and 5-HT4 receptors antagonist whose clinical development was terminated in phase II. It was being developed for the treatment of chemotherapy-induced emesis and irritable bowel syndrome.
Last Modified	11 December 2019
Downloads	Molfile

Formula	C18H19N3O
Net Charge	0
Average Mass	293.370
Monoisotopic Mass	293.15281
SMILES	Cc1ncnc1C[C@H]1CCc2c(C)c3ccccc3n2C1=O
InChI	InChI=1S/C18H19N3O/c1-11-14-5-3-4-6-17(14)21-16(11)8-7-13(18(21)22)9-15-12(2)19-10-20-15/h3-6,10,13H,7-9H2,1-2H3,(H,19,20)/t13-/m1/s1
InChIKey	AEKQMJRJRAHOAP-CYBMUJFWSA-N

Roles Classification

Biological Role:	serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
Applications:	antiemetic A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors. serotonergic antagonist Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.

ChEBI Ontology

Outgoing Relation(s)
	fabesetron (CHEBI:31588) has role antiemetic (CHEBI:50919)
	fabesetron (CHEBI:31588) has role serotonergic antagonist (CHEBI:48279)
	fabesetron (CHEBI:31588) is a imidazoles (CHEBI:24780)
	fabesetron (CHEBI:31588) is a organic heterotricyclic compound (CHEBI:26979)

IUPAC Name
(7R)-10-methyl-7-[(5-methyl-1H-imidazol-4-yl)methyl]-8,9-dihydropyrido[1,2-a]indol-6(7H)-one

INNs	Source
fabesetron	WHO MedNet
fabesetronum	WHO MedNet
fabesetrón	WHO MedNet
fabésétron	WHO MedNet

Synonyms	Source
(+)-(R)-8,9-dihydro-10-methyl-7-((5-methylimidazol-4-yl)methyl)pyrido[1,2-a]indol-6(7H)-one	ChemIDplus
FK-1052	ChEBI
FK 1052	ChEBI
FK1052	ChEBI

Registry Numbers	Sources
CAS:129300-27-2	ChemIDplus

Citations