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CHEBI:31524 - droxidopa

ChEBI IDCHEBI:31524
ChEBI Namedroxidopa
Stars
DefinitionA serine derivative that is L-serine substituted at the β-position by a 3,4-dihydroxyphenyl group. A prodrug for noradrenalone, it is used for treatment of neurogenic orthostatic hypotension
Last Modified26 January 2023
DownloadsMolfile
FormulaC9H11NO5
Net Charge0
Average Mass213.189
Monoisotopic Mass213.06372
SMILESN[C@H](C(=O)O)[C@H](O)c1ccc(O)c(O)c1
InChIInChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1
InChIKeyQXWYKJLNLSIPIN-JGVFFNPUSA-N
Wikipedia
Roles Classification
Applications:
prodrug  A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
vasoconstrictor agent  Drug used to cause constriction of the blood vessels.
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
ChEBI Ontology
Outgoing Relation(s)
droxidopa (CHEBI:31524) has role antihypertensive agent (CHEBI:35674)
droxidopa (CHEBI:31524) has role prodrug (CHEBI:50266)
droxidopa (CHEBI:31524) has role vasoconstrictor agent (CHEBI:50514)
droxidopa (CHEBI:31524) is a L-tyrosine derivative (CHEBI:27177)
droxidopa (CHEBI:31524) is a catechols (CHEBI:33566)
IUPAC Name 
(βR)-β,3-dihydroxy-L-tyrosine
INNs  Source
droxidopaKEGG DRUG
droxidopumWHO MedNet
droxidopaWHO MedNet
droxidopaWHO MedNet
Synonyms  Source
L-DihydroxyphenylserineDrugBank
L-DOPSDrugBank
L-threo-dihydroxyphenylserineDrugBank
DroxydopaHMDB
threo-DopaserineChemIDplus
SM 5688ChemIDplus
Brand Names  Source
DopsKEGG DRUG
NortheraDrugBank
Manual XrefsDatabases
D01277KEGG DRUG
DB06262DrugBank
HMDB0015627HMDB
US2008221170Patent
US2013253061Patent
JP2005247828Patent
DroxidopaWikipedia
NZ579368Patent
US2012010293Patent
971DrugCentral
Registry NumbersSources
Reaxys:7112431Reaxys
CAS:23651-95-8KEGG DRUG
CAS:23651-95-8ChemIDplus
Citations