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CHEBI:31524 - droxidopa

Default Structure
ChEBI IDCHEBI:31524
ChEBI Namedroxidopa
Stars
DefinitionA serine derivative that is L-serine substituted at the β-position by a 3,4-dihydroxyphenyl group. A prodrug for noradrenalone, it is used for treatment of neurogenic orthostatic hypotension
Last Modified26 January 2023
DownloadsMolfile
FormulaC9H11NO5
Net Charge0
Average Mass213.189
Monoisotopic Mass213.06372
SMILESN[C@H](C(=O)O)[C@H](O)c1ccc(O)c(O)c1
InChIInChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1
InChIKeyQXWYKJLNLSIPIN-JGVFFNPUSA-N
Wikipedia
Roles Classification
Applications:
vasoconstrictor agent  Drug used to cause constriction of the blood vessels.
prodrug  A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
ChEBI Ontology
Outgoing Relation(s)
droxidopa (CHEBI:31524) has role antihypertensive agent (CHEBI:35674)
droxidopa (CHEBI:31524) has role prodrug (CHEBI:50266)
droxidopa (CHEBI:31524) has role vasoconstrictor agent (CHEBI:50514)
droxidopa (CHEBI:31524) is a L-tyrosine derivative (CHEBI:27177)
droxidopa (CHEBI:31524) is a catechols (CHEBI:33566)
IUPAC Name 
(βR)-β,3-dihydroxy-L-tyrosine
INNs  Source
droxidopaWHO MedNet
droxidopaWHO MedNet
droxidopaKEGG DRUG
droxidopumWHO MedNet
Synonyms  Source
(−)-(2S,3R)-2-amino-3-hydroxy-3-(3,4-dihydroxyphenyl)propanoic acidChEBI
(2S,3R)-3,4-dihydroxy-phenylserineChEBI
DroxydopaHMDB
L-DihydroxyphenylserineDrugBank
L-DOPSDrugBank
L-threo-dihydroxyphenylserineDrugBank
Brand Names  Source
DopsKEGG DRUG
NortheraDrugBank
Manual XrefsDatabases
971DrugCentral
D01277KEGG DRUG
DB06262DrugBank
DroxidopaWikipedia
HMDB0015627HMDB
JP2005247828Patent
NZ579368Patent
US2008221170Patent
US2012010293Patent
US2013253061Patent
Registry NumbersSources
Reaxys:7112431Reaxys
CAS:23651-95-8ChemIDplus
CAS:23651-95-8KEGG DRUG
Citations