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CHEBI:31524 - droxidopa

Default Structure
ChEBI IDCHEBI:31524
ChEBI Namedroxidopa
Stars
DefinitionA serine derivative that is L-serine substituted at the β-position by a 3,4-dihydroxyphenyl group. A prodrug for noradrenalone, it is used for treatment of neurogenic orthostatic hypotension
Last Modified26 January 2023
DownloadsMolfile
FormulaC9H11NO5
Net Charge0
Average Mass213.189
Monoisotopic Mass213.06372
SMILESN[C@H](C(=O)O)[C@H](O)c1ccc(O)c(O)c1
InChIInChI=1S/C9H11NO5/c10-7(9(14)15)8(13)4-1-2-5(11)6(12)3-4/h1-3,7-8,11-13H,10H2,(H,14,15)/t7-,8+/m0/s1
InChIKeyQXWYKJLNLSIPIN-JGVFFNPUSA-N
Wikipedia
Roles Classification
Applications:
prodrug  A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
vasoconstrictor agent  Drug used to cause constriction of the blood vessels.
antiparkinson drug  A drug used in the treatment of Parkinson's disease.
cardiovascular drug  A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
ChEBI Ontology
Outgoing Relation(s)
droxidopa (CHEBI:31524) has role antihypertensive agent (CHEBI:35674)
droxidopa (CHEBI:31524) has role antiparkinson drug (CHEBI:48407)
droxidopa (CHEBI:31524) has role cardiovascular drug (CHEBI:35554)
droxidopa (CHEBI:31524) has role prodrug (CHEBI:50266)
droxidopa (CHEBI:31524) has role vasoconstrictor agent (CHEBI:50514)
droxidopa (CHEBI:31524) is a L-tyrosine derivative (CHEBI:27177)
droxidopa (CHEBI:31524) is a catechols (CHEBI:33566)
droxidopa (CHEBI:31524) is a organic molecular entity (CHEBI:50860)
droxidopa (CHEBI:31524) is a tyrosine derivative (CHEBI:62761)
IUPAC Name 
(βR)-β,3-dihydroxy-L-tyrosine
INNs  Source
droxidopaKEGG DRUG
droxidopaWHO MedNet
droxidopaWHO MedNet
droxidopumWHO MedNet
Synonyms  Source
(−)-(2S,3R)-2-amino-3-hydroxy-3-(3,4-dihydroxyphenyl)propanoic acidChEBI
(2S,3R)-3,4-dihydroxy-phenylserineChEBI
DroxydopaHMDB
L-DihydroxyphenylserineDrugBank
L-DOPSDrugBank
L-threo-dihydroxyphenylserineDrugBank
Brand Names  Source
DopsKEGG DRUG
NortheraDrugBank
Manual XrefsDatabases
971DrugCentral
D01277KEGG DRUG
DB06262DrugBank
DroxidopaWikipedia
HMDB0015627HMDB
JP2005247828Patent
NZ579368Patent
US2008221170Patent
US2012010293Patent
US2013253061Patent
Registry NumbersSources
Reaxys:7112431Reaxys
CAS:23651-95-8ChemIDplus
CAS:23651-95-8KEGG DRUG
Citations