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CHEBI:31401 - cilostazol

ChEBI IDCHEBI:31401
ChEBI Namecilostazol
Stars
DefinitionA lactam that is 3,4-dihydroquinolin-2(1H)-one in which the hydrogen at position 6 is substituted by a 4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy group.
Secondary ChEBI IDCHEBI:150440
Last Modified5 March 2020
DownloadsMolfile
FormulaC20H27N5O2
Net Charge0
Average Mass369.469
Monoisotopic Mass369.21648
SMILESO=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1
InChIInChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)
InChIKeyRRGUKTPIGVIEKM-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor  An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor which interferes with the action of 3',5'-cyclic-nucleotide phosphodiesterase (EC 3.1.4.17).
Applications:
fibrin modulating drug  A drug that affects the function of fibrin in blood coagulation.
anticoagulant  An agent that prevents blood clotting.
neuroprotective agent  Any compound that can be used for the treatment of neurodegenerative disorders.
bronchodilator agent  An agent that causes an increase in the expansion of a bronchus or bronchial tubes.
vasodilator agent  A drug used to cause dilation of the blood vessels.
platelet aggregation inhibitor  A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
ChEBI Ontology
Outgoing Relation(s)
cilostazol (CHEBI:31401) has role anticoagulant (CHEBI:50249)
cilostazol (CHEBI:31401) has role bronchodilator agent (CHEBI:35523)
cilostazol (CHEBI:31401) has role EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor (CHEBI:50568)
cilostazol (CHEBI:31401) has role fibrin modulating drug (CHEBI:48676)
cilostazol (CHEBI:31401) has role neuroprotective agent (CHEBI:63726)
cilostazol (CHEBI:31401) has role platelet aggregation inhibitor (CHEBI:50427)
cilostazol (CHEBI:31401) has role vasodilator agent (CHEBI:35620)
cilostazol (CHEBI:31401) is a lactam (CHEBI:24995)
cilostazol (CHEBI:31401) is a tetrazoles (CHEBI:35689)
IUPAC Name 
6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydroquinolin-2(1H)-one
INNs  Source
cilostazolChemIDplus
cilostazolumChemIDplus
Synonyms  Source
6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4-dihydro-1H-quinolin-2-oneChEMBL
6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-2(1H)-quinolinoneChemIDplus
6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydrocarbostyrilChemIDplus
3,4-dihydro-6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-2(1H)-quinolinoneChemIDplus
Manual XrefsDatabases
DB01166DrugBank
D01896KEGG DRUG
BE878548Patent
US4277479Patent
CilostazolWikipedia
LSM-3491LINCS
644DrugCentral
1939VSDB
Registry NumbersSources
Beilstein:3632017Beilstein
CAS:73963-72-1ChemIDplus
CAS:73963-72-1KEGG DRUG
Citations