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CHEBI:31401 - cilostazol

Default Structure
ChEBI IDCHEBI:31401
ChEBI Namecilostazol
Stars
DefinitionA lactam that is 3,4-dihydroquinolin-2(1H)-one in which the hydrogen at position 6 is substituted by a 4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy group.
Secondary ChEBI IDCHEBI:150440
Last Modified5 March 2020
DownloadsMolfile
FormulaC20H27N5O2
Net Charge0
Average Mass369.469
Monoisotopic Mass369.21648
SMILESO=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1
InChIInChI=1S/C20H27N5O2/c26-20-12-9-15-14-17(10-11-18(15)21-20)27-13-5-4-8-19-22-23-24-25(19)16-6-2-1-3-7-16/h10-11,14,16H,1-9,12-13H2,(H,21,26)
InChIKeyRRGUKTPIGVIEKM-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor  An EC 3.1.4.* (phosphoric diester hydrolase) inhibitor which interferes with the action of 3',5'-cyclic-nucleotide phosphodiesterase (EC 3.1.4.17).
Applications:
bronchodilator agent  An agent that causes an increase in the expansion of a bronchus or bronchial tubes.
vasodilator agent  A drug used to cause dilation of the blood vessels.
neuroprotective agent  Any compound that can be used for the treatment of neurodegenerative disorders.
fibrin modulating drug  A drug that affects the function of fibrin in blood coagulation.
platelet aggregation inhibitor  A drug or agent which antagonizes or impairs any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.
anticoagulant  An agent that prevents blood clotting.
ChEBI Ontology
Outgoing Relation(s)
cilostazol (CHEBI:31401) has role anticoagulant (CHEBI:50249)
cilostazol (CHEBI:31401) has role bronchodilator agent (CHEBI:35523)
cilostazol (CHEBI:31401) has role EC 3.1.4.17 (3',5'-cyclic-nucleotide phosphodiesterase) inhibitor (CHEBI:50568)
cilostazol (CHEBI:31401) has role fibrin modulating drug (CHEBI:48676)
cilostazol (CHEBI:31401) has role neuroprotective agent (CHEBI:63726)
cilostazol (CHEBI:31401) has role platelet aggregation inhibitor (CHEBI:50427)
cilostazol (CHEBI:31401) has role vasodilator agent (CHEBI:35620)
cilostazol (CHEBI:31401) is a lactam (CHEBI:24995)
cilostazol (CHEBI:31401) is a tetrazoles (CHEBI:35689)
IUPAC Name 
6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydroquinolin-2(1H)-one
INNs  Source
cilostazolChemIDplus
cilostazolumChemIDplus
Synonyms  Source
3,4-dihydro-6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-2(1H)-quinolinoneChemIDplus
6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydro-2(1H)-quinolinoneChemIDplus
6-(4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy)-3,4-dihydrocarbostyrilChemIDplus
6-[4-(1-Cyclohexyl-1H-tetrazol-5-yl)-butoxy]-3,4-dihydro-1H-quinolin-2-oneChEMBL
Manual XrefsDatabases
1939VSDB
644DrugCentral
BE878548Patent
CilostazolWikipedia
D01896KEGG DRUG
DB01166DrugBank
LSM-3491LINCS
US4277479Patent
Registry NumbersSources
Beilstein:3632017Beilstein
CAS:73963-72-1KEGG DRUG
CAS:73963-72-1ChemIDplus
Citations