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CHEBI:31399 - cilnidipine

ChEBI IDCHEBI:31399
ChEBI Namecilnidipine
Stars
DefinitionA diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive.
Secondary ChEBI IDCHEBI:551341
Last Modified13 April 2017
DownloadsMolfile
FormulaC27H28N2O7
Net Charge0
Average Mass492.528
Monoisotopic Mass492.18965
SMILESCOCCOC(=O)C1=C(C)NC(C)=C(C(=O)OC/C=C/c2ccccc2)C1c1cccc([N+](=O)[O-])c1
InChIInChI=1S/C27H28N2O7/c1-18-23(26(30)35-14-8-11-20-9-5-4-6-10-20)25(21-12-7-13-22(17-21)29(32)33)24(19(2)28-18)27(31)36-16-15-34-3/h4-13,17,25,28H,14-16H2,1-3H3/b11-8+
InChIKeyKJEBULYHNRNJTE-DHZHZOJOSA-N
Wikipedia
Roles Classification
Biological Role:
calcium channel blocker  One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools.
Applications:
cardiovascular drug  A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
ChEBI Ontology
Outgoing Relation(s)
cilnidipine (CHEBI:31399) has role antihypertensive agent (CHEBI:35674)
cilnidipine (CHEBI:31399) has role calcium channel blocker (CHEBI:38215)
cilnidipine (CHEBI:31399) has role cardiovascular drug (CHEBI:35554)
cilnidipine (CHEBI:31399) is a C-nitro compound (CHEBI:35716)
cilnidipine (CHEBI:31399) is a 2-methoxyethyl ester (CHEBI:136838)
cilnidipine (CHEBI:31399) is a dihydropyridine (CHEBI:50075)
IUPAC Name 
2-methoxyethyl (2E)-3-phenylprop-2-en-1-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
INN  Source
cilnidipineChemIDplus
Synonym  Source
(±)-(E)-cinnamyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylateChemIDplus
Manual XrefsDatabases
D01173KEGG DRUG
EP161877Patent
US4672068Patent
CilnidipineWikipedia
642DrugCentral
Registry NumbersSources
CAS:132203-70-4ChemIDplus