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CHEBI:31347 - camostat mesylate

ChEBI IDCHEBI:31347
ChEBI Namecamostat mesylate
Stars
DefinitionA methanesulfonate (mesylate) salt prepared from equimolar amounts of camostat and methanesulfonic acid. It is a serine protease inhibitor approved and marketed in Japan in 1985 for the alleviation of acute symptoms associated with chronic pancreatitis. In 1994, it was approved for the treatment of postoperative reflux esophagitis.
Last Modified13 April 2021
DownloadsMolfile
FormulaC20H22N4O5.CH4O3S
Net Charge0
Average Mass494.526
Monoisotopic Mass494.14713
SMILESCN(C)C(=O)COC(=O)Cc1ccc(OC(=O)c2ccc(NC(=N)N)cc2)cc1.CS(=O)(=O)O
InChIInChI=1S/C20H22N4O5.CH4O3S/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22;1-5(2,3)4/h3-10H,11-12H2,1-2H3,(H4,21,22,23);1H3,(H,2,3,4)
InChIKeyFSEKIHNIDBATFG-UHFFFAOYSA-N
Roles Classification
Biological Roles:
serine protease inhibitor  Any protease inhibitor that restricts the action of a serine protease.
antiviral agent  A substance that destroys or inhibits replication of viruses.
anticoronaviral agent  Any antiviral agent which inhibits the activity of coronaviruses.
Applications:
antineoplastic agent  A substance that inhibits or prevents the proliferation of neoplasms.
antifibrinolytic drug  A drug that prevent fibrinolysis or lysis of a blood clot or thrombus.
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
anti-inflammatory agent  Any compound that has anti-inflammatory effects.
ChEBI Ontology
Outgoing Relation(s)
camostat mesylate (CHEBI:31347) has part camostat(1+) (CHEBI:169939)
camostat mesylate (CHEBI:31347) has role anti-inflammatory agent (CHEBI:67079)
camostat mesylate (CHEBI:31347) has role anticoronaviral agent (CHEBI:149553)
camostat mesylate (CHEBI:31347) has role antifibrinolytic drug (CHEBI:48675)
camostat mesylate (CHEBI:31347) has role antihypertensive agent (CHEBI:35674)
camostat mesylate (CHEBI:31347) has role antineoplastic agent (CHEBI:35610)
camostat mesylate (CHEBI:31347) has role antiviral agent (CHEBI:22587)
camostat mesylate (CHEBI:31347) has role serine protease inhibitor (CHEBI:64926)
camostat mesylate (CHEBI:31347) is a methanesulfonate salt (CHEBI:38037)
IUPAC Name 
4-{2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl}phenyl 4-carbamimidamidobenzoate methanesulfonate
Synonyms  Source
camostat monomethanesulfonateChemIDplus
camostat mesilateChemIDplus
camostat methanesulfonateChEBI
N,N-dimethylcarbamoylmethyl 4-(4-guanidinobenzoyloxy)phenylacetate methanesulfateChemIDplus
amino{4-[(4-{2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl}phenoxy)carbonyl]anilino}methaniminium methanesulfonateIUPAC
Brand Names  Source
FoipanChemIDplus
FOY-305ChEBI
FOY 305ChemIDplus
FOY305ChEBI
FoistarChEBI
Manual XrefsDatabases
D01766KEGG DRUG
DBSALT002914DrugBank
39251ChemSpider
Registry NumbersSources
CAS:59721-29-8ChemIDplus
Citations