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CHEBI:31201 - amezinium metilsulfate

Default Structure
ChEBI IDCHEBI:31201
ChEBI Nameamezinium metilsulfate
Stars
DefinitionAn azaheterocycle sulfate salt of amezinium. It is a sympathomimetic drug which suppresses noradrenaline reuptake and thereby elevating blood pressure. It is used for the treatment of low blood pressure in patients undergoing dialysis.
Last Modified17 December 2019
DownloadsMolfile
FormulaC11H12N3O.CH3O4S
Net Charge0
Average Mass313.335
Monoisotopic Mass313.07324
SMILESCOS(=O)(=O)[O-].COc1cc(N)cn[n+]1-c1ccccc1
InChIInChI=1S/C11H11N3O.CH4O4S/c1-15-11-7-9(12)8-13-14(11)10-5-3-2-4-6-10;1-5-6(2,3)4/h2-8,12H,1H3;1H3,(H,2,3,4)
InChIKeyZEASXVYVFFXULL-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Roles:
sympathomimetic agent  A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
adrenergic uptake inhibitor  Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
EC 1.4.3.4 (monoamine oxidase) inhibitor  An EC 1.4.3.* (oxidoreductase acting on donor CH-NH2 group, oxygen as acceptor) inhibitor that interferes with the action of monoamine oxidase (EC 1.4.3.4).
Applications:
antihypotensive agent  A cardiovascular drug that tends to raise reduced blood pressure.
sympathomimetic agent  A drug that mimics the effects of stimulating postganglionic adrenergic sympathetic nerves. Included in this class are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.
adrenergic uptake inhibitor  Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin.
ChEBI Ontology
Outgoing Relation(s)
amezinium metilsulfate (CHEBI:31201) has part amezinium (CHEBI:145698)
amezinium metilsulfate (CHEBI:31201) has role adrenergic uptake inhibitor (CHEBI:35640)
amezinium metilsulfate (CHEBI:31201) has role antihypotensive agent (CHEBI:137431)
amezinium metilsulfate (CHEBI:31201) has role EC 1.4.3.4 (monoamine oxidase) inhibitor (CHEBI:38623)
amezinium metilsulfate (CHEBI:31201) has role sympathomimetic agent (CHEBI:35524)
amezinium metilsulfate (CHEBI:31201) is a azaheterocycle sulfate salt (CHEBI:38017)
IUPAC Name 
4-amino-6-methoxy-1-phenylpyridazin-1-ium methyl sulfate
INNs  Source
amezinii metilsulfasWHO MedNet
amezinium metilsulfateWHO MedNet
métilsulfate d'améziniumWHO MedNet
metilsulfato de amezinioWHO MedNet
Synonyms  Source
4-amino-6-methoxy-1-phenyl-pyridazinium methyl sulfateChEBI
4-amino-6-methoxy-1-phenylpyridazinium methyl sulfateChemIDplus
amezinium methyl sulfateChemIDplus
amezinium methylsulfateChEBI
LU 1631ChEBI
LU-1631ChEBI
Brand Names  Source
AcomicChEBI
AmegylChEBI
AmezininChEBI
DialeadChEBI
EpinotecChEBI
MetrocChEBI
Manual XrefsDatabases
153DrugCentral
Amezinium_metilsulfateWikipedia
D01304KEGG DRUG
DB13330DrugBank
EP0063267Patent
Registry NumbersSources
CAS:30578-37-1ChemIDplus
Citations