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CHEBI:2948 - azathioprine
| Formula | C9H7N7O2S |
| Net Charge | 0 |
| Average Mass | 277.269 |
| Monoisotopic Mass | 277.03819 |
| SMILES | Cn1cnc([N+](=O)[O-])c1Sc1ncnc2ncnc12 |
| InChI | InChI=1S/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8/h2-4H,1H3,(H,10,11,12,13) |
| InChIKey | LMEKQMALGUDUQG-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. antimetabolite A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization. DNA synthesis inhibitor Any substance that inhibits the synthesis of DNA. hepatotoxic agent A role played by a chemical compound exhibiting itself through the ability to induce damage to the liver in animals. carcinogenic agent A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities. |
| Applications: | prodrug A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| azathioprine (CHEBI:2948) has role antimetabolite (CHEBI:35221) |
| azathioprine (CHEBI:2948) has role antineoplastic agent (CHEBI:35610) |
| azathioprine (CHEBI:2948) has role carcinogenic agent (CHEBI:50903) |
| azathioprine (CHEBI:2948) has role DNA synthesis inhibitor (CHEBI:59517) |
| azathioprine (CHEBI:2948) has role hepatotoxic agent (CHEBI:50908) |
| azathioprine (CHEBI:2948) has role immunosuppressive agent (CHEBI:35705) |
| azathioprine (CHEBI:2948) has role prodrug (CHEBI:50266) |
| azathioprine (CHEBI:2948) is a C-nitro compound (CHEBI:35716) |
| azathioprine (CHEBI:2948) is a aryl sulfide (CHEBI:35683) |
| azathioprine (CHEBI:2948) is a imidazoles (CHEBI:24780) |
| azathioprine (CHEBI:2948) is a thiopurine (CHEBI:35666) |
| IUPAC Name |
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| 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-7H-purine |
| Synonyms | Source |
|---|---|
| 6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine | ChemIDplus |
| 6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine | ChemIDplus |
| Imuran (TN) | KEGG DRUG |
| Citations |
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