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CHEBI:2948 - azathioprine
| Formula | C9H7N7O2S |
| Net Charge | 0 |
| Average Mass | 277.269 |
| Monoisotopic Mass | 277.03819 |
| SMILES | Cn1cnc([N+](=O)[O-])c1Sc1ncnc2ncnc12 |
| InChI | InChI=1S/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8/h2-4H,1H3,(H,10,11,12,13) |
| InChIKey | LMEKQMALGUDUQG-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. hepatotoxic agent A role played by a chemical compound exhibiting itself through the ability to induce damage to the liver in animals. DNA synthesis inhibitor Any substance that inhibits the synthesis of DNA. carcinogenic agent A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities. antiviral agent A substance that destroys or inhibits replication of viruses. antimetabolite A substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization. |
| Applications: | antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. antifibrotic agent Any agent which acts to reduce fibrosis. renoprotective agent Any compound that is able to prevent damage to the kidneys. anti-inflammatory agent Any compound that has anti-inflammatory effects. anti-anaemic agent A compound which increases either the number of red cells or the amount of haemoglobin in the blood. dermatologic drug A drug used to treat or prevent skin disorders or for the routine care of skin. prodrug A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug. gout suppressant A drug that increases uric acid excretion by the kidney (uricosuric drug), decreases uric acid production (antihyperuricemic), or alleviates the pain and inflammation of acute attacks of gout. antirheumatic drug A drug used to treat rheumatoid arthritis. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| azathioprine (CHEBI:2948) has role anti-anaemic agent (CHEBI:75835) |
| azathioprine (CHEBI:2948) has role anti-inflammatory agent (CHEBI:67079) |
| azathioprine (CHEBI:2948) has role antifibrotic agent (CHEBI:233423) |
| azathioprine (CHEBI:2948) has role antimetabolite (CHEBI:35221) |
| azathioprine (CHEBI:2948) has role antineoplastic agent (CHEBI:35610) |
| azathioprine (CHEBI:2948) has role antirheumatic drug (CHEBI:35842) |
| azathioprine (CHEBI:2948) has role antiviral agent (CHEBI:22587) |
| azathioprine (CHEBI:2948) has role carcinogenic agent (CHEBI:50903) |
| azathioprine (CHEBI:2948) has role dermatologic drug (CHEBI:50177) |
| azathioprine (CHEBI:2948) has role DNA synthesis inhibitor (CHEBI:59517) |
| azathioprine (CHEBI:2948) has role gout suppressant (CHEBI:35845) |
| azathioprine (CHEBI:2948) has role hepatotoxic agent (CHEBI:50908) |
| azathioprine (CHEBI:2948) has role immunosuppressive agent (CHEBI:35705) |
| azathioprine (CHEBI:2948) has role prodrug (CHEBI:50266) |
| azathioprine (CHEBI:2948) has role renoprotective agent (CHEBI:231911) |
| azathioprine (CHEBI:2948) is a C-nitro compound (CHEBI:35716) |
| azathioprine (CHEBI:2948) is a aryl sulfide (CHEBI:35683) |
| azathioprine (CHEBI:2948) is a imidazoles (CHEBI:24780) |
| azathioprine (CHEBI:2948) is a thiopurine (CHEBI:35666) |
| IUPAC Name |
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| 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-7H-purine |
| INN | Source |
|---|---|
| azatioprina | WHO MedNet |
| Synonyms | Source |
|---|---|
| 6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine | ChemIDplus |
| 6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine | ChemIDplus |
| Azathioprine | ChEMBL |
| Azathioprinum | ChEMBL |
| BW-57-322 | ChEMBL |
| Imuran (TN) | KEGG DRUG |
| Brand Names | Source |
|---|---|
| Azapress | ChEMBL |
| Azasan | ChEMBL |
| Berkaprine | ChEMBL |
| Immunoprin 50 | ChEMBL |
| Imuran | ChEMBL |
| Jayempi | ChEMBL |
| Citations |
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