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CHEBI:2922 - auranofin
| Formula | C20H34AuO9PS |
| Net Charge | 0 |
| Average Mass | 678.491 |
| Monoisotopic Mass | 678.13268 |
| SMILES | CC[P+](CC)(CC)[Au-][S][C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O |
| InChI | InChI=1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18;1-4-7(5-2)6-3;/h10-14,24H,5H2,1-4H3;4-6H2,1-3H3;/q;;+1/p-1/t10-,11-,12+,13-,14+;;/m1../s1 |
| InChIKey | AUJRCFUBUPVWSZ-XTZHGVARSA-M |
| Wikipedia |
|---|
| Roles Classification |
|---|
| Biological Roles: | immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. EC 1.8.1.9 (thioredoxin reductase) inhibitor An EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of thioredoxin reductase (EC 1.8.1.9). |
| Applications: | antirheumatic drug A drug used to treat rheumatoid arthritis. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| auranofin (CHEBI:2922) has role antirheumatic drug (CHEBI:35842) |
| auranofin (CHEBI:2922) has role EC 1.8.1.9 (thioredoxin reductase) inhibitor (CHEBI:64670) |
| auranofin (CHEBI:2922) has role immunosuppressive agent (CHEBI:35705) |
| auranofin (CHEBI:2922) is a S-glycosyl compound (CHEBI:35275) |
| auranofin (CHEBI:2922) is a gold coordination entity (CHEBI:33971) |
| IUPAC Name |
|---|
| (2,3,4,6-tetra-O-acetyl-1-thio-β-D-glucopyranosato-κS1)(triethylphosphine)gold |
| INNs | Source |
|---|---|
| auranofin | KEGG DRUG |
| auranofina | ChemIDplus |
| auranofine | ChemIDplus |
| auranofinum | ChemIDplus |
| Synonyms | Source |
|---|---|
| (1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate | ChemIDplus |
| 2,3,4,6-Tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S (triethylphosphine)gold | ChemIDplus |
| Triethylphosphine gold | ChemIDplus |
| Brand Name | Source |
|---|---|
| Ridaura | KEGG DRUG |
| Citations |
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