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CHEBI:2922 - auranofin
| Formula | C20H34AuO9PS |
| Net Charge | 0 |
| Average Mass | 678.491 |
| Monoisotopic Mass | 678.13268 |
| SMILES | CC[P+](CC)(CC)[Au-][S][C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O |
| InChI | InChI=1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18;1-4-7(5-2)6-3;/h10-14,24H,5H2,1-4H3;4-6H2,1-3H3;/q;;+1/p-1/t10-,11-,12+,13-,14+;;/m1../s1 |
| InChIKey | AUJRCFUBUPVWSZ-XTZHGVARSA-M |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. anti-HIV agent An antiviral agent that destroys or inhibits the replication of the human immunodeficiency virus. antitubercular agent A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis. EC 1.8.1.9 (thioredoxin reductase) inhibitor An EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of thioredoxin reductase (EC 1.8.1.9). analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. |
| Applications: | antirheumatic drug A drug used to treat rheumatoid arthritis. antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. antitubercular agent A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. antiamoebic agent An antiparasitic agent which is effective against amoeba, a genus of single-celled amoeboids in the family Amoebidae. |
| ChEBI Ontology |
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| Outgoing Relation(s) |
| auranofin (CHEBI:2922) has role analgesic (CHEBI:35480) |
| auranofin (CHEBI:2922) has role anti-HIV agent (CHEBI:64946) |
| auranofin (CHEBI:2922) has role antiamoebic agent (CHEBI:171664) |
| auranofin (CHEBI:2922) has role antineoplastic agent (CHEBI:35610) |
| auranofin (CHEBI:2922) has role antirheumatic drug (CHEBI:35842) |
| auranofin (CHEBI:2922) has role antitubercular agent (CHEBI:33231) |
| auranofin (CHEBI:2922) has role EC 1.8.1.9 (thioredoxin reductase) inhibitor (CHEBI:64670) |
| auranofin (CHEBI:2922) has role immunosuppressive agent (CHEBI:35705) |
| auranofin (CHEBI:2922) is a S-glycosyl compound (CHEBI:35275) |
| auranofin (CHEBI:2922) is a gold coordination entity (CHEBI:33971) |
| IUPAC Name |
|---|
| (2,3,4,6-tetra-O-acetyl-1-thio-β-D-glucopyranosato-κS1)(triethylphosphine)gold |
| INNs | Source |
|---|---|
| auranofin | KEGG DRUG |
| auranofina | ChemIDplus |
| auranofine | ChemIDplus |
| auranofinum | ChemIDplus |
| Synonyms | Source |
|---|---|
| (1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate | ChemIDplus |
| 2,3,4,6-Tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S (triethylphosphine)gold | ChemIDplus |
| NSC-321521 | ChEMBL |
| SK-39162 | ChEMBL |
| SK&F 39162 | ChEMBL |
| SK&F-39162 | ChEMBL |
| Brand Name | Source |
|---|---|
| Ridaura | KEGG DRUG |
| Citations |
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