EMBL-EBI | Chemical Biology | ChEBI
Example searches: iron*, InChI=1S/CH4O/c1-2/h2H,1H3, caffeine | Advanced Search
CHEBI:2922 - auranofin
| Formula | C20H34AuO9PS |
| Net Charge | 0 |
| Average Mass | 678.491 |
| Monoisotopic Mass | 678.13268 |
| SMILES | CC[P+](CC)(CC)[Au-][S][C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O |
| InChI | InChI=1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18;1-4-7(5-2)6-3;/h10-14,24H,5H2,1-4H3;4-6H2,1-3H3;/q;;+1/p-1/t10-,11-,12+,13-,14+;;/m1../s1 |
| InChIKey | AUJRCFUBUPVWSZ-XTZHGVARSA-M |
| Wikipedia |
|---|
| Roles Classification |
|---|
| Biological Roles: | immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. EC 1.8.1.9 (thioredoxin reductase) inhibitor An EC 1.8.1.* (oxidoreductase acting on sulfur group of donors, NAD+ or NADP+ as acceptor) inhibitor that interferes with the action of thioredoxin reductase (EC 1.8.1.9). |
| Applications: | immunosuppressive agent An agent that suppresses immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-cells or by inhibiting the activation of helper cells. In addition, an immunosuppressive agent is a role played by a compound which is exhibited by a capability to diminish the extent and/or voracity of an immune response. antirheumatic drug A drug used to treat rheumatoid arthritis. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| auranofin (CHEBI:2922) has role antirheumatic drug (CHEBI:35842) |
| auranofin (CHEBI:2922) has role EC 1.8.1.9 (thioredoxin reductase) inhibitor (CHEBI:64670) |
| auranofin (CHEBI:2922) has role immunosuppressive agent (CHEBI:35705) |
| auranofin (CHEBI:2922) is a S-glycosyl compound (CHEBI:35275) |
| auranofin (CHEBI:2922) is a gold coordination entity (CHEBI:33971) |
| IUPAC Name |
|---|
| (2,3,4,6-tetra-O-acetyl-1-thio-β-D-glucopyranosato-κS1)(triethylphosphine)gold |
| INNs | Source |
|---|---|
| auranofin | KEGG DRUG |
| auranofina | ChemIDplus |
| auranofine | ChemIDplus |
| auranofinum | ChemIDplus |
| Synonyms | Source |
|---|---|
| (1-Thio-beta-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate | ChemIDplus |
| 2,3,4,6-Tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S (triethylphosphine)gold | ChemIDplus |
| Triethylphosphine gold | ChemIDplus |
| Brand Name | Source |
|---|---|
| Ridaura | KEGG DRUG |
| Citations |
|---|