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CHEBI:28502 - tolazoline

ChEBI IDCHEBI:28502
ChEBI Nametolazoline
Stars
DefinitionA member of the class of imidazoles that is 4,5-dihydro-1H-imidazole substituted by a benzyl group.
Secondary ChEBI IDsCHEBI:9614, CHEBI:27018
Last Modified22 February 2017
DownloadsMolfile
FormulaC10H12N2
Net Charge0
Average Mass160.220
Monoisotopic Mass160.10005
SMILESc1ccc(CC2=NCCN2)cc1
InChIInChI=1S/C10H12N2/c1-2-4-9(5-3-1)8-10-11-6-7-12-10/h1-5H,6-8H2,(H,11,12)
InChIKeyJIVZKJJQOZQXQB-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
alpha-adrenergic antagonist  An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
Applications:
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
vasodilator agent  A drug used to cause dilation of the blood vessels.
alpha-adrenergic antagonist  An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
ChEBI Ontology
Outgoing Relation(s)
tolazoline (CHEBI:28502) has role antihypertensive agent (CHEBI:35674)
tolazoline (CHEBI:28502) has role vasodilator agent (CHEBI:35620)
tolazoline (CHEBI:28502) has role α-adrenergic antagonist (CHEBI:37890)
tolazoline (CHEBI:28502) is a imidazoles (CHEBI:24780)
IUPAC Name 
2-benzyl-4,5-dihydro-1H-imidazole
Synonyms  Source
TolazolineKEGG COMPOUND
4,5-Dihydro-2-(phenylmethyl)-1H-imidazoleKEGG COMPOUND
2-Benzyl-2-imidazolineChemIDplus
2-Benzyl-4,5-imidazolineChemIDplus
2-BenzylimidazolineChemIDplus
Manual XrefsDatabases
C07147KEGG COMPOUND
TolazolineWikipedia
DB00797DrugBank
HMDB0014935HMDB
D08614KEGG DRUG
LSM-3020LINCS
2695DrugCentral
Registry NumbersSources
Reaxys:128757Reaxys
CAS:59-98-3KEGG COMPOUND
CAS:59-98-3ChemIDplus
CAS:59-98-3NIST Chemistry WebBook
Citations