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CHEBI:28502 - tolazoline

Default Structure
ChEBI IDCHEBI:28502
ChEBI Nametolazoline
Stars
DefinitionA member of the class of imidazoles that is 4,5-dihydro-1H-imidazole substituted by a benzyl group.
Secondary ChEBI IDsCHEBI:9614, CHEBI:27018
Last Modified22 February 2017
DownloadsMolfile
FormulaC10H12N2
Net Charge0
Average Mass160.220
Monoisotopic Mass160.10005
SMILESc1ccc(CC2=NCCN2)cc1
InChIInChI=1S/C10H12N2/c1-2-4-9(5-3-1)8-10-11-6-7-12-10/h1-5H,6-8H2,(H,11,12)
InChIKeyJIVZKJJQOZQXQB-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
alpha-adrenergic antagonist  An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
Applications:
alpha-adrenergic antagonist  An agent that binds to but does not activate α-adrenergic receptors thereby blocking the actions of endogenous or exogenous α-adrenergic agonists. α-Adrenergic antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
antihypertensive agent  Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
vasodilator agent  A drug used to cause dilation of the blood vessels.
ChEBI Ontology
Outgoing Relation(s)
tolazoline (CHEBI:28502) has role antihypertensive agent (CHEBI:35674)
tolazoline (CHEBI:28502) has role vasodilator agent (CHEBI:35620)
tolazoline (CHEBI:28502) has role α-adrenergic antagonist (CHEBI:37890)
tolazoline (CHEBI:28502) is a imidazoles (CHEBI:24780)
IUPAC Name 
2-benzyl-4,5-dihydro-1H-imidazole
Synonyms  Source
2-Benzyl-2-imidazolineChemIDplus
2-Benzyl-4,5-imidazolineChemIDplus
2-BenzylimidazolineChemIDplus
4,5-Dihydro-2-(phenylmethyl)-1H-imidazoleKEGG COMPOUND
TolazolineKEGG COMPOUND
Manual XrefsDatabases
2695DrugCentral
C07147KEGG COMPOUND
D08614KEGG DRUG
DB00797DrugBank
HMDB0014935HMDB
LSM-3020LINCS
TolazolineWikipedia
Registry NumbersSources
Reaxys:128757Reaxys
CAS:59-98-3NIST Chemistry WebBook
CAS:59-98-3ChemIDplus
CAS:59-98-3KEGG COMPOUND
Citations