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CHEBI:2718 - angiotensin I

ChEBI IDCHEBI:2718
ChEBI Nameangiotensin I
Stars
DefinitionA ten amino acid peptide formed by renin cleavage of angiotensinogen. Angiotensin I has no direct biological function except that high levels can stimulate catecholamine production. It is metabolized to its biologically active byproduct angiotensin II, a potent vasoconstrictor, by angiotensin converting enzyme (ACE) through cleavage of the two terminal amino acids.
Last Modified9 April 2020
DownloadsMolfile
FormulaC62H89N17O14
Net Charge0
Average Mass1296.499
Monoisotopic Mass1295.67749
SMILESCC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(=O)N[C@@H](Cc1cncn1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cncn1)C(=O)N[C@@H](CC(C)C)C(=O)O
InChIInChI=1S/C62H89N17O14/c1-7-35(6)51(78-56(87)44(25-37-17-19-40(80)20-18-37)74-58(89)50(34(4)5)77-53(84)42(15-11-21-68-62(64)65)71-52(83)41(63)28-49(81)82)59(90)75-46(27-39-30-67-32-70-39)60(91)79-22-12-16-48(79)57(88)73-43(24-36-13-9-8-10-14-36)54(85)72-45(26-38-29-66-31-69-38)55(86)76-47(61(92)93)23-33(2)3/h8-10,13-14,17-20,29-35,41-48,50-51,80H,7,11-12,15-16,21-28,63H2,1-6H3,(H,66,69)(H,67,70)(H,71,83)(H,72,85)(H,73,88)(H,74,89)(H,75,90)(H,76,86)(H,77,84)(H,78,87)(H,81,82)(H,92,93)(H4,64,65,68)/t35-,41-,42-,43-,44-,45-,46-,47-,48-,50-,51-/m0/s1
InChIKeyORWYRWWVDCYOMK-HBZPZAIKSA-N
Species of MetaboliteComponentSourceComments
Homo sapiens (ncbitaxon:9606) blood plasma (BTO_0000131) PubMed (8142230)
Roles Classification
Chemical Roles:
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Bronsted base  A molecular entity capable of accepting a hydron from a donor (Brønsted acid).
Biological Roles:
neurotransmitter agent  A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.
human metabolite  Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
hormone  Originally referring to an endogenous compound that is formed in specialized organ or group of cells and carried to another organ or group of cells, in the same organism, upon which it has a specific regulatory function, the term is now commonly used to include non-endogenous, semi-synthetic and fully synthetic analogues of such compounds.
Application:
neurotransmitter agent  A substance used for its pharmacological action on any aspect of neurotransmitter systems. Neurotransmitter agents include agonists, antagonists, degradation inhibitors, uptake inhibitors, depleters, precursors, and modulators of receptor function.
ChEBI Ontology
Outgoing Relation(s)
angiotensin I (CHEBI:2718) has role human metabolite (CHEBI:77746)
angiotensin I (CHEBI:2718) has role neurotransmitter agent (CHEBI:35942)
angiotensin I (CHEBI:2718) is a angiotensin (CHEBI:48433)
angiotensin I (CHEBI:2718) is tautomer of angiotensin I dizwitterion (CHEBI:147350)
Incoming Relation(s)
angiotensin I dizwitterion (CHEBI:147350) is tautomer of angiotensin I (CHEBI:2718)
IUPAC Name 
L-α-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucine
Synonyms  Source
angiotensin IKEGG COMPOUND
proangiotensinChemIDplus
pepsitensinChemIDplus
Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-LeuMetaCyc
DRVYIHPFHLChEBI
D-R-V-Y-I-H-P-F-H-LChEBI
Manual XrefsDatabases
C00873KEGG COMPOUND
HMDB0061196HMDB
CPD-13004MetaCyc
WO2009040072Patent
Registry NumbersSources
CAS:9041-90-1ChemIDplus
Citations