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CHEBI:27999 - tolbutamide
| Formula | C12H18N2O3S |
| Net Charge | 0 |
| Average Mass | 270.354 |
| Monoisotopic Mass | 270.10381 |
| SMILES | CCCCNC(=O)NS(=O)(=O)c1ccc(C)cc1 |
| InChI | InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15) |
| InChIKey | JLRGJRBPOGGCBT-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Species of Metabolite | Component | Source | Comments |
|---|---|---|---|
| Homo sapiens (ncbitaxon:9606) | - | DOI (10.1038/nbt.2488) |
| Roles Classification |
|---|
| Biological Roles: | potassium channel blocker An agent that inhibits cell membrane glycoproteins that are selectively permeable to potassium ions. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. insulin secretagogue A secretagogue that causes the secretion of insulin. antiviral agent A substance that destroys or inhibits replication of viruses. human metabolite Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens). |
| Applications: | antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. analgesic An agent capable of relieving pain without the loss of consciousness or without producing anaesthesia. In addition, analgesic is a role played by a compound which is exhibited by a capability to cause a reduction of pain symptoms. hypoglycemic agent A drug which lowers the blood glucose level. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| tolbutamide (CHEBI:27999) has role analgesic (CHEBI:35480) |
| tolbutamide (CHEBI:27999) has role antineoplastic agent (CHEBI:35610) |
| tolbutamide (CHEBI:27999) has role antiviral agent (CHEBI:22587) |
| tolbutamide (CHEBI:27999) has role human metabolite (CHEBI:77746) |
| tolbutamide (CHEBI:27999) has role hypoglycemic agent (CHEBI:35526) |
| tolbutamide (CHEBI:27999) has role insulin secretagogue (CHEBI:90415) |
| tolbutamide (CHEBI:27999) has role potassium channel blocker (CHEBI:50509) |
| tolbutamide (CHEBI:27999) is a N-sulfonylurea (CHEBI:76983) |
| IUPAC Name |
|---|
| N-[(butylamino)carbonyl]-4-methylbenzenesulfonamide |
| INNs | Source |
|---|---|
| tolbutamida | ChemIDplus |
| tolbutamide | ChemIDplus |
| tolbutamidum | ChemIDplus |
| Synonyms | Source |
|---|---|
| 1-Butyl-3-(p-methylphenylsulfonyl)urea | ChemIDplus |
| 1-Butyl-3-(p-tolylsulfonyl)urea | ChemIDplus |
| 1-Butyl-3-tosylurea | ChemIDplus |
| 1-p-Toluenesulfonyl-3-butylurea | ChemIDplus |
| 3-(p-Tolyl-4-sulfonyl)-1-butylurea | ChemIDplus |
| Butamide | ChEMBL |
| Brand Names | Source |
|---|---|
| Glyconon | ChEMBL |
| Orinase | ChEMBL |
| Pramidex | ChEMBL |
| Rastinon | ChEMBL |
| Citations |
|---|