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CHEBI:2686 - amrinone

ChEBI IDCHEBI:2686
ChEBI Nameamrinone
Stars
DefinitionA 3,4'-bipyridine substituted at positions 5 and 6 by an amino group and a keto function respectively. A pyridine phosphodiesterase 3 inhibitor, it is a drug that may improve the prognosis in patients with congestive heart failure.
Secondary ChEBI IDCHEBI:95269
Last Modified17 May 2024
DownloadsMolfile
FormulaC10H9N3O
Net Charge0
Average Mass187.202
Monoisotopic Mass187.07456
SMILESNc1cc(-c2ccncc2)cnc1=O
InChIInChI=1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)
InChIKeyRNLQIBCLLYYYFJ-UHFFFAOYSA-N
Wikipedia
Roles Classification
Biological Role:
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor  An EC 3.1.* (ester hydrolase) inhibitor that interferes with the action of a phosphoric diester hydrolase (EC 3.1.4.*).
Application:
cardiovascular drug  A drug that affects the rate or intensity of cardiac contraction, blood vessel diameter or blood volume.
ChEBI Ontology
Outgoing Relation(s)
amrinone (CHEBI:2686) has role cardiovascular drug (CHEBI:35554)
amrinone (CHEBI:2686) has role EC 3.1.4.* (phosphoric diester hydrolase) inhibitor (CHEBI:50218)
amrinone (CHEBI:2686) is a bipyridines (CHEBI:50511)
IUPAC Name 
5-amino[3,4'-bipyridin]-6(1H)-one
INNs  Source
amrinoneWHO MedNet
amrinonaWHO MedNet
amrinoneWHO MedNet
amrinonumWHO MedNet
Synonyms  Source
inamrinoneKEGG DRUG
WIN-40680DrugBank
WIN 40680DrugBank
5-amino-1,6-dihydro-6-oxo-[3,4'-bipyridine]ChEBI
3-amino-5-(4-pyridinyl)-1,2-dihydro-2-pyridoneChEBI
3-amino-5-pyridin-4-yl-1H-pyridin-2-oneChEBI
Manual XrefsDatabases
D00231KEGG DRUG
LSM-6600LINCS
201DrugCentral
AmrinoneWikipedia
DB01427DrugBank
HMDB0015496HMDB
Registry NumbersSources
CAS:60719-84-8DrugCentral
CAS:60719-84-8ChemIDplus
Citations