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CHEBI:2675 - amoxapine
| Formula | C17H16ClN3O |
| Net Charge | 0 |
| Average Mass | 313.788 |
| Monoisotopic Mass | 313.09819 |
| SMILES | Clc1ccc2c(c1)C(N1CCNCC1)=Nc1ccccc1O2 |
| InChI | InChI=1S/C17H16ClN3O/c18-12-5-6-15-13(11-12)17(21-9-7-19-8-10-21)20-14-3-1-2-4-16(14)22-15/h1-6,11,19H,7-10H2 |
| InChIKey | QWGDMFLQWFTERH-UHFFFAOYSA-N |
| Wikipedia |
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| Roles Classification |
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| Biological Roles: | dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. |
| Applications: | geroprotector Any compound that supports healthy aging, slows the biological aging process, or extends lifespan. dopaminergic antagonist A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists. adrenergic uptake inhibitor Adrenergic uptake inhibitors are drugs that block the transport of adrenergic transmitters into axon terminals or into storage vesicles within terminals. The tricyclic antidepressants and amphetamines are among the therapeutically important drugs that may act via inhibition of adrenergic transport. Many of these drugs also block transport of serotonin. serotonin uptake inhibitor A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent. antidepressant Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| amoxapine (CHEBI:2675) has role adrenergic uptake inhibitor (CHEBI:35640) |
| amoxapine (CHEBI:2675) has role antidepressant (CHEBI:35469) |
| amoxapine (CHEBI:2675) has role dopaminergic antagonist (CHEBI:48561) |
| amoxapine (CHEBI:2675) has role geroprotector (CHEBI:176497) |
| amoxapine (CHEBI:2675) has role serotonin uptake inhibitor (CHEBI:50949) |
| amoxapine (CHEBI:2675) is a dibenzooxazepine (CHEBI:53802) |
| IUPAC Name |
|---|
| 2-chloro-11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazepine |
| INNs | Source |
|---|---|
| amoxapine | KEGG DRUG |
| amoxapina | ChemIDplus |
| amoxapinum | ChemIDplus |
| Synonyms | Source |
|---|---|
| 2-Chloro-11-(1-piperazinyl)dibenz(b,f)(1,4)oxazepine | NIST Chemistry WebBook |
| Desmethylloxapin | ChemIDplus |
| Registry Numbers | Sources |
|---|---|
| Beilstein:832057 | Beilstein |
| CAS:14028-44-5 | KEGG DRUG |
| CAS:14028-44-5 | DrugBank |
| CAS:14028-44-5 | ChemIDplus |
| CAS:14028-44-5 | NIST Chemistry WebBook |
| Citations |
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