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CHEBI:2636 - amifostine
| Formula | C5H15N2O3PS |
| Net Charge | 0 |
| Average Mass | 214.227 |
| Monoisotopic Mass | 214.05410 |
| SMILES | NCCCNCCSP(=O)(O)O |
| InChI | InChI=1S/C5H15N2O3PS/c6-2-1-3-7-4-5-12-11(8,9)10/h7H,1-6H2,(H2,8,9,10) |
| InChIKey | JKOQGQFVAUAYPM-UHFFFAOYSA-N |
| Wikipedia |
|---|
| Roles Classification |
|---|
| Chemical Roles: | antioxidant A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides. Bronsted base A molecular entity capable of accepting a hydron from a donor (Brønsted acid). |
| Applications: | antineoplastic agent A substance that inhibits or prevents the proliferation of neoplasms. prodrug A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug. anti-anaemic agent A compound which increases either the number of red cells or the amount of haemoglobin in the blood. radiation protective agent Any compound that is able to protect normal cells from the damage caused by radiation therapy. |
| ChEBI Ontology |
|---|
| Outgoing Relation(s) |
| amifostine (CHEBI:2636) has functional parent cysteamine (CHEBI:17141) |
| amifostine (CHEBI:2636) has role anti-anaemic agent (CHEBI:75835) |
| amifostine (CHEBI:2636) has role antineoplastic agent (CHEBI:35610) |
| amifostine (CHEBI:2636) has role antioxidant (CHEBI:22586) |
| amifostine (CHEBI:2636) has role prodrug (CHEBI:50266) |
| amifostine (CHEBI:2636) has role radiation protective agent (CHEBI:66987) |
| amifostine (CHEBI:2636) is a diamine (CHEBI:23666) |
| amifostine (CHEBI:2636) is a organic thiophosphate (CHEBI:37512) |
| IUPAC Name |
|---|
| S-{2-[(3-aminopropyl)amino]ethyl} dihydrogen thiophosphate |
| INNs | Source |
|---|---|
| amifostina | ChEBI |
| amifostine | ChemIDplus |
| amifostinum | ChEBI |
| Synonyms | Source |
|---|---|
| Amifostine | KEGG COMPOUND |
| Amifostine anhydrous | ChEMBL |
| Amifostine disulfide | ChEMBL |
| Ethiofos anhydrous | ChEMBL |
| NSC-296961 | ChEMBL |
| NSC-758236 | ChEMBL |
| Brand Name | Source |
|---|---|
| Ethyol | DrugBank |
| Manual Xrefs | Databases |
|---|---|
| 156 | DrugCentral |
| Amifostine | Wikipedia |
| C06819 | KEGG COMPOUND |
| DB01143 | DrugBank |
| HMDB0015274 | HMDB |
| LSM-4721 | LINCS |
| US3892824 | Patent |
| Registry Numbers | Sources |
|---|---|
| Reaxys:2088122 | Reaxys |
| CAS:20537-88-6 | ChemIDplus |
| Citations |
|---|